检验医学与临床2023，Vol.20Issue(24)：3658-3661,3667,5.DOI:10.3969/j.issn.1672-9455.2023.24.017
CEA、CA125、CA199对消化道神经内分泌肿瘤的诊断价值研究
Study on diagnostic value of CEA,CA125 and CA199 in gastrointestinal neuroendocrine neoplasms
阮长龙 1石瀚枫 2马成明 3杭玉捷 1孙泽群 1王仲霞1
作者信息
- 1. 湖北省十堰市人民医院/湖北医药学院附属人民医院消化内科,湖北十堰 442099
- 2. 湖北省十堰市丹江口市第一医院消化内科,湖北十堰 442799
- 3. 湖北省十堰市郧西县人民医院感染科,湖北十堰 442699
- 折叠
摘要
Abstract
Objective To investigate the diagnostic value of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 199(CA199)in gastrointestinal neuroendocrine neoplasms(GI-NENs).Methods Forty-five patients with GI-NENs admitted and treated in Shiyan Municipal People's Hospital from March 2010 to May 2021 were taken as the experimental group and 45 healthy subjects under-going physical examination in the same period were taken as the control group.The differences of CEA,CA125 and CA199 levels between the two groups were analyzed,the Logistic regression analysis model was constructed,and the receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic effi-ciency of CEA,CA125 and CA199 single item detection and their combined detection for diagnosing GI-NENs.Results The levels of CEA and CA125 in the experimental group were significantly higher than those in the control group,and the difference was statistically significant(P＜0.05).The proportion of CEA,CA125 and CA199 increase had statistical difference between the two groups(P＜0.05).The difference in the proportion of CEA level increase among the patients with different pathological grades of GI-NENs had statistical signifi-cance(P＜0.05);while the proportion of CA125 and CA199 levels increase had no statistical significance(P＞0.05).There was no statistically significant difference in the proportion of CEA,CA125,and CA199 lev-els increase between the patients with or without lymph node metastasis(P＞0.05).The increase of CEA and CA125 levels was the risk factor for the GI-NENs occurrence(P＜0.05).The areas under the ROC curves(AUC)of CEA and CA125 detection alone for diagnosing GI-NENs were 0.672(95％CI:0.561-0.784)and 0.674(95％CI:0.563-0.784)respectively,which were lower than 0.735(95％CI:0.632-0.838)of CEA and CA125 combined detection for diagnosing GI-NENs,and the differences were statistically significant(P＜0.05).Conclusion The CEA and CA125 levels in the patients with GI-NENs are significantly increased,mo-reover the increase of CEA and CA125 levels is the risk factor for GI-NENs occurrence.The combined detec-tion of CEA and CA125 levels has certain diagnostic value for GI-NENs.关键词
消化道神经内分泌肿瘤/癌胚抗原/CA125/CA19 9Key words
gastroint estinal neuroendocrine neoplasma/carcinoembryonic antigen/CA125/CA199分类
医药卫生引用本文复制引用
阮长龙,石瀚枫,马成明,杭玉捷,孙泽群,王仲霞..CEA、CA125、CA199对消化道神经内分泌肿瘤的诊断价值研究[J].检验医学与临床,2023,20(24):3658-3661,3667,5.
