摘要
Abstract
Objective To compare the efficacy of different doses of somatostatin combined with endoscopic loop ligation in the treatment of liver cirrhosis complicating gastrointestinal bleeding and its effect on the co-agulation function.Methods Ninety-six patients with liver cirrhosis complicating gastrointestinal bleeding ad-mitted and treated in this hospital from January 2020 to March 2022 were selected as the research subjects and divided into the conventional dose group and high dose group according to the random number table method.The both groups underwent the endoscopic loop ligation surgery.The conventional dose group was given the conventional dose of somatostatin(0.25 μg/h continuous pump infusion),high-dose group received the high dose somatostatin(0.50 μg/h continuous pump injection,all administered for 5 d.The surgical indicators liga-tion indicators,rebleeding rate,efficacy,adverse reactions,coagulation function,adverse reactions,and inci-dence rate of complications within one month after surgery wer compared between the two groups.Results The recovery time of postoperative bowel sounds and hospitalization time in the high dose group were shorter than those in the conventional dose group(P＜0.05).The total effective rate of the high dose group was higher than that of the conventional dose group(97.92％vs.85.42％,P＜0.05).The incidence of early rebleeding in the high-dose group was 4.17％,while in the conventional dose group was 18.75％,and the difference between the two groups was statistically significant(P＜0.05).There was no statistically signifi-cant difference in the loop ligation frequency,number of ligation rings,postoperative hemostasis rate and inci-dence rate of delayed rebleeding between the two groups(P＞0.05).The TT,PT,and APTT after treatment in the both groups were shortened,while the FIB level was increased,and the differences were statistically sig-nificant(P＜0.05);moreover,TT,PT,and APTT after treatment,in the high dose group were shorter than those in the conventional dose group,and the FIB level was higher than that in the conventional dose group,with statistical significance(P＜0.05).The adverse reaction rate of the conventional dose group was 6.25％,and the adverse reaction rate of the high-dose group was 12.50％.There was no significant difference in the incidence rate of adverse reactions between the two groups(P=0.484).The complication rate of the conven-tional dose group was 2.08％,and the complication rate of the high-dose group was 4.17％.There was no significant difference in the incidence rate of complications between the two groups(P=0.557).Conclusion The use of high-dose somatostatin combined with endoscopic ligation for patients with liver cirrhosis and gastrointestinal bleeding can improve surgical outcomes,accelerate postoperative recovery,and improve coagulation function.It is also safe and effective,and is worth promoting.关键词
生长抑素/内镜下套扎术/肝硬化/消化道出血/凝血功能Key words
somatostatin/endoscopic ligation/cirrhosis/gastrointestinal bleeding/coagulation function分类
医药卫生
