兰州大学学报（医学版）2023，Vol.49Issue(10)：10-15,25,7.DOI:10.13885/j.issn.1000-2812.2023.10.002
血清重金属与胃癌发病风险的巢式病例对照研究
A nested case-control study on the serum heavy metals and the risk of gastric cancer
摘要
Abstract
Objective To investigate the effects of serum copper,cobalt and lead on the risk of gastric cancer.Methods Using the Jinchang cohort as the data platform,a total of 148 newly diagnosed gastric cancer patients during the three follow-up periods from 2014 to 2020 were collected as the case group,and 592 con-trols were obtained by 1∶4 individual matching according to the same gender and age(±2 years).Conditional Logistic regression model was used to explore the relationship between the serum levels of three heavy metals and the risk of gastric cancer.Restricted cubic spline method was used to analyze the dose-response relation-ship between the two.Results Multivariate conditional Logistic regression analysis showed that the risk of gastric cancer increased by 108%(OR = 2.08,95%CI:[1.18,3.66])in serum copper level of≥990.63 μg·L-1 compared with serum copper level of[100.00,853.14]μg·L-1.Compared to serum cobalt level of 0.20 μg·L-1,the risk of gastric cancer increased by 730%(OR = 8.30,95%CI:[4.48,15.35])and 883%(OR = 9.83,95%CI:[5.14,18.79])in serum cobalt levels of[0.21,0.35]μg·L-1 and≥0.36 μg·L-1,respectively.And compared to se-rum lead level of≤4.00 μg·L-1,the risk of gastric cancer increased by 108%(OR = 2.08,95%CI:[1.29,3.35])when serum lead level≥4.01 μg·L-1.There was a dose-response relationship between serum copper,cobalt and lead levels and the risk of gastric cancer.Conclusion This study found serum copper,cobalt and lead were risk factors for gastric cancer.The serum levels of heavy metals should be regularly monitored in the population.关键词
重金属暴露/胃癌/Logistic回归模型/剂量-反应关系/巢式病例对照研究/金昌队列Key words
heavy metal exposure/gastric cancer/Logistic regression model/dose-response relationship/nest-ed case-control study/Jinchang cohort分类
医药卫生引用本文复制引用
陈蕊蕊,张德生,张李珍,夏智恒,王仲阁,张甜,豆倩,李拥军,白亚娜..血清重金属与胃癌发病风险的巢式病例对照研究[J].兰州大学学报（医学版）,2023,49(10):10-15,25,7.基金项目
金川集团公司职工代谢性疾病全程管理体系建设资助项目(金科综2020-02) （金科综2020-02）
