临床口腔医学杂志2023，Vol.39Issue(12)：707-711,5.DOI:10.3969/j.issn.1003-1634.2023.12.002
光动力金属有机框架PCN对粪肠球菌杀灭效果的体外研究
Effect of photodynamic metal-organic framework PCN on Enterococcus faecalis in vitro
摘要
Abstract
Objective:To investigate the efficacy of photodynamic metal-organic framework PCN in killing Enterococ-cus faecalis in vitro.Methods:PCN was characterized by scanning electron microscopy(SEM)and full-wavelength enzymo-graph.The biosafety of PCN was verified by cell viability assay.The antibacterial properties of PCN in vitro were verified by gradient dilution counting.Results:PCN nanoparticles have strong ability of generating active oxygen and good biosafety.In vitro experiments showed that the concentration of 50 μg/mL could completely kill Enterococcus faecalis at the order of 108 CFU/mL,which had excellent antibacterial properties in vitro.Conclusion:This study verified the efficacy of photody-namic metal-organic framework PCN in killing Enterococcus faecalis,providing a new way for clinical root canal infection control.关键词
根管感染/粪肠球菌/多孔配位网络/光动力抗菌疗法Key words
Root canal infection/Enterococcus faecalis/Porous coordination network/Photodynamic antimicrobial therapy分类
医药卫生引用本文复制引用
董绘华,张栌丹,王宇光..光动力金属有机框架PCN对粪肠球菌杀灭效果的体外研究[J].临床口腔医学杂志,2023,39(12):707-711,5.基金项目
国家自然科学基金项目(编号51972003) （编号51972003）
