临床口腔医学杂志2023，Vol.39Issue(12)：722-726,5.DOI:10.3969/j.issn.1003-1634.2023.12.005
PNI和SII与头颈癌患者术后谵妄的相关性研究
Correlation analysis of prognostic nutritional index and systemic immune-inflammatory index with postopera-tive delirium in head and neck cancer patients
摘要
Abstract
Objective:To investigate the incidence and risk factors of postoperative delirium(POD)after in patients with head and neck cancer(HNC)and explore the correlation between prognostic nutritional index(PNI)and systemic im-mune-inflammation index(SII)with POD in head and neck cancer patients.Methods:A retrospective analysis of 206 patients in who were performed the radical resection with cervical lymph node dissection for HNC in the Xuzhou Central Hospital be-tween January 2017 to May 2023.Of the 206 patients,126 were male and 80 were female,aged 65～79 years with a mean of(60.80±12.51)years.Analysis of POD-related risk factors with SPSS 26.0 software package,and Logistic regression was used to screen for independent risk factors.Results:A total of 29(14.1%)patients had postoperative delirium.Single factor analysis results indicated that delirium was associated with age≥60 years old,male,tumor site,smoking,PNI,SII,total pro-tein,tracheostomy,blood transfusion,free flap reconstruction,time of operation,postoperative fever,sleep disturbance,ICU monitoring time,pneumonia,flap crisis,visual analogue scale/scores(VAS),length of hospital stay.Multiple logistic regres-sion analysis showed that the independent risk factors of delirium included age≥60 years old(OR=6.381,95%CI 1.218～33.421),PNI(OR=0.793,95%CI 0.649～0.970),SII(OR=1.002,95%CI 1.000～1.003),transfusion(OR=7.551,95%CI 1.180～48.320),sleep disturbance(OR= 7.411,95%CI 1.067～51.482),ICU monitoring time(OR= 3.879,95%CI 1.399～10.753),VAS scores(OR=1.648,95%CI 1.016～2.674).Conclusion:PNI and SII have good predictive values for POD in head and neck cancer patients,and it can be used to screen high-risk patients of POD.They have the potential to be-come a new routine tool for identifying patients who at high risk of POD.关键词
头颈癌/术后谵妄/预后营养指数/系统免疫炎症指数/危险因素Key words
Head and neck cancer/Postoperative delirium/Prognostic nutritional index/System immune inflamma-tion index/Risk factor analysis分类
医药卫生引用本文复制引用
沈梦圆,王雅娇,徐欣晨,李晓东,孟箭..PNI和SII与头颈癌患者术后谵妄的相关性研究[J].临床口腔医学杂志,2023,39(12):722-726,5.基金项目
国家口腔疾病临床医学研究中心开放课题(NCRCO-202101) （NCRCO-202101）
徐州市科技计划项目(KC21187) （KC21187）
徐州医科大学附属医院优秀人才基金项目(XYFY2020035) （XYFY2020035）
徐州医科大学附属医院优秀人才基金项目(XYFY202207) （XYFY202207）
