临床神经外科杂志2023，Vol.20Issue(6)：677-681,685,6.DOI:10.3969/j.issn.1672-7770.2023.06.014
44例少突胶质细胞瘤的临床病理观察
Clinicopathological observation of 44 cases with oligodendroglioma
摘要
Abstract
Objective To investigate the pathological morphology,immunophenotype,clinical manifestation and prognosis of oligodendroglioma with isocitrate dehydrogenase(IDH)mutation and 1p/19q co-deletion.Methods The clinical data of 44 patients with oligodendroglioma admitted to the Affiliated Hospital of Xuzhou Medical University from January 2018 to December 2022 were analyzed retrospectively.Combined with the comprehensive interpretation of their histomorphology,immunophenotype and molecular detection results,the diagnosis and classification were carried out according to the 2021 World Health Organization(WHO)classification criteria for central nervous system tumors.And the relevant literature was reviewed to analyze their clinical and pathological characteristics.Results All 44 patients were diagnosed as oligodendroglioma.There were 18 patients with WHO grade Ⅱ,with an average age of 43.4 years,and 26 patients with WHO gradeⅢ,with an average age of 51.3 years.Most of the tumors were located in the frontal lobe of the brain.They were grayish red and soft.Microscopically,tumor cells with different cell densities could be seen infiltrating and growing towards the brain parenchyma.44 cases showed IDH1-R132H positive by immunohistochemistry and expressed ATRX,GFAP,Olig-2,et al.And fluorescence in situ hybridization showed 1p/19q co-deletion.Conclusions Oligodendroglioma is a rare diffuse infiltrating glioma with relatively poor treatment response and poor prognosis.In morphology,it should be differentiated from central neurocytoma,astrocytoma,glioblastoma,neuroectodermal tumor,lymphoma,etc.It is easy to be misdiagnosed.The diagnosis should be improved and combined with histopathology and fish gene detection results.关键词
少突胶质细胞瘤/1p/19q共缺失/IDH突变/鉴别诊断/预后Key words
oligodendroglioma/1p/19q co-deletion/IDH mutation/differential diagnosis/prognosis分类
医药卫生引用本文复制引用
赵雅娴,夏蕾,刘慧,李凤朝,李琛..44例少突胶质细胞瘤的临床病理观察[J].临床神经外科杂志,2023,20(6):677-681,685,6.基金项目
徐州市重点研发计划(社会发展)基金资助项目(KC21207) （社会发展）
