临床与实验病理学杂志2023，Vol.39Issue(11)：1322-1327,1333,7.DOI:10.13315/j.cnki.cjcep.2023.11.008
黏附G蛋白偶联受体GPR110辅助诊断腺泡型和实体型肺腺癌的临床意义
Clinical significance of adhesion G protein-coupled receptor GPR110 in distinguishing acinar and solid lung adenocarcinoma
何超楠 1余科科 2牛永杰 3张叶1
作者信息
- 1. 上海市胸科医院/上海交通大学医学院附属胸科医院生物样本库,上海 200030
- 2. 上海市胸科医院/上海交通大学医学院附属胸科医院生物样本库,上海 200030||上海市胸科医院/上海交通大学医学院附属胸科医院科教部,上海 200030
- 3. 上海市胸科医院/上海交通大学医学院附属胸科医院胸部肿瘤研究所,上海 200030
- 折叠
摘要
Abstract
Purpose To explore the differential expression of GPR110,an adherent G protein-coupled receptor,and its role in the differential diagnosis of acinar and solid adenocarcinoma of the lung.Methods The expression level of GPR110 was de-termined by immunohistochemistry(IHC),qRT-PCR and ELISA,and ROC and area under the curve(AUC)were ana-lyzed to distinguish the acinar predominant and solid predomi-nant of lung adenocarcinoma,so as to evaluate the role of differ-ential GPR110 expression in the differential diagnosis of these two histopathological subtypes with different prognosis.Results The expression of GPR110 in lung adenocarcinoma tumor tis-sue was significantly higher than that in adjacent tissue,and its expression in solid predominant lung adenocarcinoma was signifi-cantly higher than that in acinar predominant.The average con-centrations of GPR110 protein in 100 pairs of acinar predominant lung adenocarcinoma tumor tissues and its adjacent tissues were 430.53 and 313.26 ng/L by ELISA.The average concentrations of GPR110 protein in 53 pairs of solid predominant lung adeno-carcinoma tumor tissues and its adjacent tissues were 716.56 and 368.46 ng/L,and the differences were statistically signifi-cant(P＜0.001).At the same time,the ROC curve showed that the GPR110 protein had a sensitivity of 77.36％,a speci-ficity of 83.00％,an optimal Cut-off value of 582.27 ng/L,and an AUC of 0.865(0.802-0.927).Conclusion GPR110 has potential application value in the differential diagnosis of acinar type and solid type of adenocarcinoma of the lung,and it is ex-pected to become a new biomarker for differential diagnosis关键词
肺肿瘤/腺癌/GPR110/病理亚型/生物学标志物Key words
lung neoplasm/adenocarcinoma/GPR110/patholog-ical subtype/biomarker分类
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何超楠,余科科,牛永杰,张叶..黏附G蛋白偶联受体GPR110辅助诊断腺泡型和实体型肺腺癌的临床意义[J].临床与实验病理学杂志,2023,39(11):1322-1327,1333,7.
