岭南现代临床外科2023，Vol.23Issue(5)：392-398,7.DOI:10.3969/j.issn.1009-976X.2023.05.004
基于铜死亡相关基因的胶质瘤预后模型构建
Construction of prognosis model for glioma based oncuproptosis related genes
张博弘 1张祺2
作者信息
- 1. 中山大学附属第七医院科研中心,广东深圳 518107||中山大学附属第七医院麻醉科,广东深圳 518107
- 2. 中山大学附属第七医院麻醉科,广东深圳 518107
- 折叠
摘要
Abstract
Objective To construct a prognostic model for glioma patients based on cuproptosis related genes.Methods The transcriptome expression profiles of normal brain tissues were downloaded from GTEx database.The transcriptome expression profiles and corresponding clinical data of glioma patients were downloaded from TCGA and GEO databases.Differential expression analysis and prognostic analysis were performed on the 12 CRGs.Firstly,according to the expression profile of prognostic CRGs,the glio-ma samples were classified into different cuproptosis subtypes by consensus clustering algorithm.Prognos-tic DEGs between different cuproptosis subtypeswere obtained.Then,Lasso Cox regression analysis was used to construct the prognostic risk score model,and ROC curve was used to evaluate the predictive per-formance of this model.Finally,nomogram was constructed to improve the clinical applicability of the prognosis model.Results A total of 720 glioma samples were obtained.Using the consensus cluster-ing algorithm,glioma samples were classified into two cuproptosis subtypes,CRGcluster A and CRGclus-ter B.A total of 1831 differentially expressed genes related to prognosis were identifiedbetween the two cuproptosis subtypes.A prognostic risk score model with eight genes was constructed in the train set and validated in the test set.ROC curve analysis showed that the AUC of the model in predicting the 1-,3-and 5-year survival rates of glioma patients in the test set were 0.881,0.894 and 0.874.According to the prognosis model,glioma samples were classified into high-risk group and low-risk group,and patients in the high-risk group had lower survival rate and shorter survival time(P<0.05).Conclusion In this study,a prognostic risk score model for glioma was constructed based on cuproptosis related genes.This model can accurately predict the prognosis of patients with glioma,which provides a new way to evaluate the prognosis of patients with glioma.关键词
胶质瘤/铜死亡/预后Key words
glioma/cuproptosis/prognosis分类
医药卫生引用本文复制引用
张博弘,张祺..基于铜死亡相关基因的胶质瘤预后模型构建[J].岭南现代临床外科,2023,23(5):392-398,7.
