岭南现代临床外科2023，Vol.23Issue(5)：418-423,6.DOI:10.3969/j.issn.1009-976X.2023.05.009
3例原发性甲状腺滤泡性淋巴瘤的临床分析及文献复习
Clinical analysis of 3 cases primary thyroid follicular lymphoma and literature review
摘要
Abstract
Objective To explore the clinical manifestations,pathological features,immunophenotype,differential diagnosis,treatment and prognosis of primary thyroid follicular lymphoma(PTFL).Methods The clinical data of three patients with PTFL were retrospectively analyzed,and the therapy strategy and follow-up prognosis were sorted out and analyzed.Results All three patients underwent surgery.One of them was confirmed as FL by pathological diagnosis,and regular chemotherapy after surgery.This patient was followed up for more than 3 years and completely remission(CR).The postoperative pathological diagnosis of other one was not clear,for the results didn't support typical FL.However,the Bcl-2-negative PTFL couldn't be exclude.This case was in stable condition after followed up for more than 6 years without any further examination or chemotherapy.The last case had difficulties in pathological diagnosis,and finally diagnosed as FL by pathology specialist consultation.Then the patient was treated with 1 course CD20 monoclonal antibody and followed up for over 1 year,CR.Conclusion PTFL is rare in clinical practice and is prone to misdiagnosed or missed.By collecting 3 cases of PTFL for clinical analysis,the differential diagnosis ideas were provided and the basis for formulating individualized clinical treatment strategies were provided.关键词
甲状腺/滤泡性淋巴瘤/病理诊断/治疗/预后Key words
thyroid/follicular lymphoma/pathological diagnosis/therapy/follow-up分类
医药卫生引用本文复制引用
蔡雷琴,胡宇坤,任萌,黄楚霖,余君言,孙侃,严励,王晓艺,徐明彤,张锦,吴木潮..3例原发性甲状腺滤泡性淋巴瘤的临床分析及文献复习[J].岭南现代临床外科,2023,23(5):418-423,6.基金项目
国家自然科学基金青年项目(82000784) （82000784）
广东省代谢性疾病(糖尿病)临床医学研究中心(2020B1111170009) （糖尿病）
