中南医学科学杂志2023，Vol.51Issue(6)：803-807,5.DOI:10.15972/j.cnki.43-1509/r.2023.06.002
细胞表型转化在心血管疾病发生发展中的作用机制
Role and mechanism of the cell phenotypic transformation in the occurrence and de-velopment of cardiovascular diseases
摘要
Abstract
Although great advances have made in prevention,early diagnosis and treatment of cardiovascular dis-ease,this disease remains the leading cause of death and disability worldwide.Therefore,clarifying the pathogenesis of cardiovascular diseases and exploring the therapeutic targets of cardiovascular diseases are critical for the early treatment of cardiovascular diseases,as well as the prevention of adverse cardiovascular events.Cell phenotypic transformation refers to the biological process in which cells lose their specific phenotypic characteristics and acquire another phenotypic charac-teristic,which is closely related to the occurrence of cardiovascular diseases.Therefore,this paper summarizes the poten-tial functions of macrophage polarization,vascular smooth muscle cell phenotypic transformation,and endothelial-to-mesen-chymal transition in the occurrence and development of cardiovascular diseases,hoping to demonstrate the mechanism of cardiovascular diseases through the joint efforts of the majority of researchers.关键词
心血管疾病/细胞表型转化/巨噬细胞/血管平滑肌细胞/内皮细胞Key words
cardiovascular disease/cell phenotypic transformation/macrophages/vascular smooth muscle cells/endothelial cells分类
医药卫生引用本文复制引用
赵国军,侯连杰..细胞表型转化在心血管疾病发生发展中的作用机制[J].中南医学科学杂志,2023,51(6):803-807,5.基金项目
国家自然科学基金面上项目(81870337,82300517) （81870337,82300517）
广州医科大学 2022 年度学生创新能力提升计划项目(2022-66) （2022-66）
