中南医学科学杂志2023，Vol.51Issue(6)：818-823,6.DOI:10.15972/j.cnki.43-1509/r.2023.06.005
巨噬细胞功能M1/M2极性化在心血管疾病中的研究进展
Research progress of macrophage M1/M2 polarization in cardiovascular diseases
摘要
Abstract
Macrophages are the main components of innate immune system,with plasticity and heterogeneity.Macrophages play an important role in immune response,tissue homeostasis and remodeling.According to functional po-larity,it can be divided into two subtypes:M1(pro-inflammatory)and M2(anti-inflammatory).M1/M2 macrophages,in response to local microenvironment stimuli,obtain specific functional phenotypes and secrete different cytokines by alte-ring their functional polarization.Macrophages adapt to their functional changes by altering metabolic reprogramming.M2 macrophages acquire their energy mainly through oxidative phosphorylation and fatty acid oxidation,while M1 macro-phages use aerobic glycolysis.It has been shown that macrophages may participate in the pathogenesis of cardiovascular diseases through the changes in their functional polarity,which may cause macrophage activation,tissue infiltration and re-lease of inflammatory cytokines.This article reviews the role of functional polarization and metabolic reprogramming of macrophages in cardiovascular diseases.关键词
巨噬细胞/极化/代谢重编程/心血管疾病Key words
macrophage/polarization/metabolic reprogramming/cardiovascular disease分类
医药卫生引用本文复制引用
张晓天,任昊麟,亢梦婕,周明生..巨噬细胞功能M1/M2极性化在心血管疾病中的研究进展[J].中南医学科学杂志,2023,51(6):818-823,6.基金项目
国家自然科学基金项目(82270434,81970357) （82270434,81970357）
沈阳医学院硕士研究生科技创新基金(Y20220506) （Y20220506）
