中南医学科学杂志2023，Vol.51Issue(6)：824-828,5.DOI:10.15972/j.cnki.43-1509/r.2023.06.006
巨噬细胞在心肌梗死后成纤维细胞激活中的作用
The role of macrophages in the activation of fibroblasts after myocardial infarction
摘要
Abstract
Macrophages play an important regulatory role in the inflammation and fibrosis process after myocardial infarction.Macrophages are classified into CCR2+ macrophages and CCR2-macrophages based on the presence or absence of CC chemokine receptor 2(CCR2)expression.CCR2-macrophages are classified into pro-inflammatory Ly6Chi CCR2hi CX3CR1lo macrophages and anti-inflammatory Ly6Clo CCR2lo CX3CR1hi macrophages according to the expres-sion level of Ly6C.Ly6Chi macrophages produce inflammatory cytokines in the early stage and acute inflammatory phase after myocardial infarction,whereas Ly6Clo macrophages are recruited in the later stage after infarction,secreting anti-in-flammatory cytokines and growth factors.Macrophages directly activate fibroblasts by paracrine inflammatory factors such as interleukin(IL)-1β,IL-6 and tumor necrosis factor-α,or indirectly play a role in activation of fibroblasts by promoting the expression of transforming growth factor-β.This article provides a review of macrophage sources in the myocardium and their role in fibroblast activation after myocardial infarction.关键词
巨噬细胞/心肌梗死/成纤维细胞Key words
macrophage/myocardial infarction/fibroblast分类
医药卫生引用本文复制引用
周昊,张颖倩,胡颖芸,陈润都,马明睿,李越洋,陈韵岱..巨噬细胞在心肌梗死后成纤维细胞激活中的作用[J].中南医学科学杂志,2023,51(6):824-828,5.基金项目
国家重大科研仪器研制项目(81827808) （81827808）
