中南医学科学杂志2023，Vol.51Issue(6)：886-889,4.DOI:10.15972/j.cnki.43-1509/r.2023.06.020
允许性高碳酸对肺叶切除术老年患者炎症刺激和认知功能的影响
Effects of permissive hypercapnia on inflammatory stress and cognitive function in elderly patients undergoing pulmonary lobectomy
摘要
Abstract
Aim To explore the effects of permissive hypercapnia(PHC)on inflammatory stress and cognitive function in elderly patients undergoing pulmonary lobectomy.Methods One hundred and twenty elderly patients un-dergoing lobectomy were selected,and randomly assigned into PHC group[partial pressure of carbon dioxide(PCO2)ran-ging from 45 to 55 mmHg]and control group(PCO2 ranging from 35 to 45 mmHg),each with 60 cases.The mean arte-rial blood pressure and heart rate were recorded during surgery.Serum concentrations of adrenaline,cortisol and tumor necrosis factor α(TNF-α)were measured by using ELISH at the baseline,5 minutes after anaesthesia induction,end of surgery and 24 h after surgery.The mini-mental state examination(MMSE)score at baseline and 7 days after surgery,as well as the incidence rate of postoperative cognitive dysfunction(POCD)at postoperative 7 days,were compared between two groups.Results No statistical difference was observed between two groups in mean arterial blood pressure and heart rate during operation(P>0.05).A reduction in MMSE score was observed in both groups,and PHC group scored higher on MMSE than control group at 7-daypost-operation.The incidence rate of POCD at 7-day post operation was lower in PHC group than in control group(P<0.05).Serum concentrations of adrenaline,cortisol and TNF-α at 24h post-op-eration as well as cortisol concentration at the end of surgery were all lower in PHC group than in control group(P<0.05).Conclusion PHC can effectively prevent cognitive dysfunction after pulmonary lobectomy in the elderly,which may be re-lated with the alleviation in stress and inflammatoryresponse.关键词
允许性高碳酸血症/肺叶切除术/老年/POCD/应激反应/炎症反应Key words
permissive hypercapnia/pulmonary lobectomy/elderly patient/POCD/stress response/in-flammatory response分类
医药卫生引用本文复制引用
崔芝红,姚娜娜,朱贤林..允许性高碳酸对肺叶切除术老年患者炎症刺激和认知功能的影响[J].中南医学科学杂志,2023,51(6):886-889,4.基金项目
湖北省自然科学基金项目(2016CFB368) （2016CFB368）
