品牌与标准化Issue(1)：39-42,4.DOI:10.3969/j.issn.1674-4977.2024.01.012
高效液相色谱法测定化妆品中4种防晒剂的方法研究
Study on the Determination of 4 Sunscreen Agents in Cosmetics by High Performance Liquid Chromatography
刘阳 1李野1
作者信息
- 1. 辽宁省药品审评查验中心,辽宁 沈阳 110036
- 折叠
摘要
Abstract
A high performance liquid chromatography(HPLC)method was established for the detection of 4 chemical sunscreen agents,Drometrizole trisiloxane,Ethylhexyltriazone,Methylenebis-benzotriazolyltetramethylbutylphenol and Bis-ethylhexyloxyphenol methoxyphenyl triazine.The target compounds were separated by Symmetry C18 column,and analyzed by HPLC with PDA detector.Water+ perchloric acid(300+0.25)-methanol-tetrahydrofuran was used as mobile phase for gradient elution.The flow rate was 1.0 mL/min,the column temperature was 35℃,and the detection wavelength was 311 nm.The samples were extracted by ultrasonic extraction of tetrahydrofuran and quantified by external standard method.The recoveries range from 96.3％to 108.6％and RSD range from 0.32％to 2.38％at both high and low levels,indicating that the method has high accuracy for the determination of 4 sunscreen agents in cosmetics.关键词
高效液相色谱法/化妆品/防晒剂Key words
high performance liquid chromatography/cosmetics/sunscreen引用本文复制引用
刘阳,李野..高效液相色谱法测定化妆品中4种防晒剂的方法研究[J].品牌与标准化,2024,(1):39-42,4.
