日用化学工业（中英文）2023，Vol.53Issue(12)：1429-1436,8.DOI:10.3969/j.issn.2097-2806.2023.12.010
透明质酸锌的护肤功效研究
Study on the skin care efficacy of zinc hyaluronate
郭海姣 1王晓娜 1杨素珍 1袁春颖 1任轩 1韩婷婷1
作者信息
- 1. 山东福瑞达生物股份有限公司,山东 济南 250101
- 折叠
摘要
Abstract
With zinc hyaluronate of different molecular weight as the research object,the in vitro moisturizing,oil control,firming and soothing effects were studied by the zebrafish mosturiztion test,the lipid drop detection of sebacogland cell SZ95,the inhibition of 5α reductase,the proliferation of fibroblasts,the detection of typeⅠ collagen content,and the inhibition of inflammatory factor of macrophages.The results show that 0.5% zinc hyaluronate can inhibit the water loss caused by high osmotic pressure of zebrafish and has significant moisturizing effect.Large molecules of zinc hyaluronate can achieve oil control effect by inhibiting 5α reductase.Medium and small molecules of zinc hyaluronate can achieve oil control effect by inhibiting the synthesis of lipid droplets and inhibiting 5α reductase.Small molecules of zinc hyaluronic acid can promote fibroblast proliferation in a dose-dependent way.Collagen I formation is significantly promoted by medium molecules of zinc hyaluronic acid at 125,12.5 and 1.25 μg/mL.The expressions of IL-1α,TNF-α and PGE 2 are significantly inhibited by large,medium and small molecules of zinc hyaluronate at the mass concentrations of 25 and 125 μg/mL.Experiments show that zinc hyaluronate has good moisturizing,oil control,firming,and soothing effect.关键词
透明质酸锌/保湿/控油/紧致/舒缓Key words
zinc hyaluronate/moisturize/oil control/firming/soothing分类
化学化工引用本文复制引用
郭海姣,王晓娜,杨素珍,袁春颖,任轩,韩婷婷..透明质酸锌的护肤功效研究[J].日用化学工业（中英文）,2023,53(12):1429-1436,8.
