日用化学工业（中英文）2023，Vol.53Issue(12)：1443-1450,8.DOI:10.3969/j.issn.2097-2806.2023.12.012
液质联用技术在化妆品抗感染类药物检测中的应用
Application of liquid chromatography-mass spectrometry in the detection of anti-infective drugs in cosmetics
摘要
Abstract
The effects and safety risks of adding anti-infective drugs in cosmetics were summarized.The common types,characteristics and application fields of liquid chromatography-mass spectrometry were introduced.The methods in"Safety and Technical Standards for Cosmetics(2015 Edition)"for determination of anti-infective drugs were also listed in this paper.The advantages of various detection methods were introduced,including liquid chromatography triple quadrupole tandem mass spectrometry(LC-MS/MS),direct real-time analysis-high resolution mass spectrometry(DART-Q-Exactive-Orbitrap-MS),ultra-performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UPLC-Q-Orbitrap MS),ultra high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry(UPLC-LTQ/orbitrap MS)and ultra high performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry(UPLC-Q-TOF-MS).In the sample screening process,some scholars detected three compounds that had not yet been detected in the"Safety and Technical Standards for Cosmetics(2015 Edition)",namely danofloxacin,trimethoprim and ronidazole.This paper can provide data for the relevant scientific research work in cosmetics.At the same time,the risk monitoring work of cosmetics in relevant testing institution will have direction and ideas after understanding the above content.In addition,the exploratory research on the correction of detection method will be more efficient and scientific.Finally,the trend of using liquid chromatography-mass spectrometry to establish methods for determination of anti-infective drugs in cosmetics is recommended.Liquid chromatography-mass spectrometry is still the preferred method for the determination of anti-infective drugs in cosmetics in the future.Above all,high resolution mass spectrometry will be more widely used in the confirmation of known substances and screening of unknown substances.关键词
液质联用技术/化妆品/抗感染类药物/检测方法Key words
liquid chromatography-mass spectrometry/cosmetics/anti-infective drugs/detection method分类
化学化工引用本文复制引用
胡贝,李丽霞,丁晓萍,吕稳,李晓健,李琼..液质联用技术在化妆品抗感染类药物检测中的应用[J].日用化学工业（中英文）,2023,53(12):1443-1450,8.基金项目
湖北省药品监督检验研究院中青年科研项目(2022YN002) （2022YN002）
