日用化学工业（中英文）2023，Vol.53Issue(12)：1451-1458,8.DOI:10.3969/j.issn.2097-2806.2023.12.013
用于抗糖化功效评价的细胞模型研究现状及应用前景
Cell model research status and application prospects for the evaluation of anti-glycation efficacy
曹晨灿 1谭淇丹 1刘蕾 1杨小玉 1陈海峰1
作者信息
- 1. 北京工商大学 化学与材料工程学院 植物资源研究开发北京市重点实验室,北京 100048
- 折叠
摘要
Abstract
This paper reviews the mechanism of glycation reaction,the classification of advanced glycation end products(AGEs),the effects of glycation on skin,the evaluation methods of anti-glycation efficacy and the current research status of the cell models used for the evaluation of anti-glycation efficacy at home and abroad.According to the different cell functions,the application of five types of keratinocytes(HaCaT),fibroblasts,immune cells(RAW264.7/THP-1),melanocytes and vascular endothelial cells(HUVECs)in the evaluation cell model of anti-glycation efficacy was summarized.They are aimed at the skin barrier damage,collagen loss,pigmentation,oxidative stress and inflammation caused by glycation.According to the different modeling stimulation modes,the application of three stimulation modes of high glucose,methylglyoxal/glyoxal(MGO/GO)and AGEs in the cell model of glycation injury was summarized,aiming at the early stage,middle and late stage of the mechanism of glycation reaction and the action stage of AGEs.This review looks forward to the application prospect of cell models for anti-glycation efficacy evaluation,in order to provide an experimental basis for the establishment of standard methods for anti-glycation efficacy evaluation cell models and provide a theoretical basis for the screening of anti-glycation efficacy raw materials.关键词
抗糖化/细胞模型/化妆品功效评价/晚期糖化终产物(AGEs)Key words
anti-glycation/cell model/cosmetic efficacy evaluation/advanced glycation end products(AGEs)分类
化学化工引用本文复制引用
曹晨灿,谭淇丹,刘蕾,杨小玉,陈海峰..用于抗糖化功效评价的细胞模型研究现状及应用前景[J].日用化学工业（中英文）,2023,53(12):1451-1458,8.
