四川医学2023，Vol.44Issue(11)：1133-1139,7.DOI:10.16252/j.cnki.issn1004-0501-2023.11.003
赌博障碍患者脑功能连接研究的Meta分析
Brain Network Dysfunction in Gambling Disorder:A Meta-Analysis of Functional Connectivity
摘要
Abstract
Objective To present a Meta-analysis of task-state and resting-state functional connectivity(FC)findings in specific brain networks in patients with gambling disorder(GD),and aims to clarify the neural mechanisms underlying the abnormal behaviours of GD.Methods PubMed,Cochrane,Web of Science,EMBASE,CNKI,Wanfang Data,and VIP were searched.All seed-based FC studies published from inception to May 2022 were included.Meta-analysis was then performed by usingactivation likelihood estimation(ALE).Results 9 publications(166 GD and 170 healthy controls)survived the screening were included.The meta-analysis showed that compared with healthy controls,the connectivity within limbic network(LN)and default mode network(DMN)in GD were increased.The between-network connectivity of DMN-dorsal attention network(DAN),DMN-excutive control network(ECN),DMN-sensory network,LN-DMN,LN-DAN,LN-right frontoparietal network(FPN)were increased.Conclusion Results suggest that functional network alteration in individuals with GD may link to their abnormal behaviors,including the weak-ened self-control,increased reward sensitivity,attention allocation disorder,and self-related mental activity disorder.Our findings provide a reference for further research on the neural mechanism of behavioral nonsubstance addiction disorders and the treatment of GD.关键词
赌博障碍/Meta分析/功能连接/激活似然估计/脑网络Key words
gambling disorder/Meta-analysis/functional connectivity/activation likelihood estimation/brian networks分类
医药卫生引用本文复制引用
严睿桐,王洋,蒋苹..赌博障碍患者脑功能连接研究的Meta分析[J].四川医学,2023,44(11):1133-1139,7.基金项目
四川省自然科学青年科学基金项目(编号:2022NSFSC1454) （编号:2022NSFSC1454）
