山东中医杂志2023，Vol.42Issue(12)：1274-1281,8.DOI:10.16295/j.cnki.0257-358x.2023.12.006
软肝化积丸对瘀血内结型丙型肝炎肝硬化患者纤维化指标和炎症因子的影响
Effect of Ruangan Huaji Pill(软肝化积丸)on Fibrosis Index and Inflammatory Factor in Patients with Hepatitis C Cirrhosis of Blood Stasis Type
摘要
Abstract
Objective:To observe the effects of Ruangan Huaji Pill(软肝化积丸)on fibrosis index[aspartate aminotransferase-alanine aminotransferase ratio(AAR)],liver fibrosis index(FIB-4)and inflam-matory factors in patients with ecstatic hepatitis C cirrhosis.Methods:A total of 101 patients with hepatitis C cirrhosis were selected and divided into observation group 50 patients(1 case dropout)and control group 51 cases(2 cases dropouts)according to random number table method.Patients in control group were given conventional western medicine treatment,while patients in observation group were further given Ruangan Huaji Pill treatment.Continuous treatment for 3 months.Levels of interleukin-10(IL-10),stromal cell derived factor 1(SDF-1),chemokine receptor 4(CXCR4),aspartate aminotransferase(AST),alanine aminotransferase(ALT),platelet value(PLT)and type Ⅲprecollagen(P Ⅲ NP),type Ⅳ collagen(CIV),hyaluronidase(HA)and laminin(LN)were detected before and after treatment,AAR,FIB-4 index,liver stiffness,portal venous flow,portal vein diameter,portal vein velocity,and spleen thickness were measured,and TCM syndrome scores and clinical efficacy of the observation group and control group were compared,and adverse reactions occurred during treatment between the two groups were recorded.Results:After treatment levels of IL-10,SDF-1,CXCR4,AST,ALT,PⅢ NP,CIV,HA,LN,scores of FIB-4 index and AAR,liver hardness,portal vein diameter,spleen thickness and TCM syndrome score in observation group were significantly lower than those in control group(P＜0.05).The portal vein velocity,portal venous flow and total effectiveness rate in the observation group were significantly higher than those in the control group(P＜0.05),and no significant adverse reactions occurred in both groups.Conclusions:Ruangan Huaji Pill can improve the levels of anti-inflammatory factors and pro-inflammatory factors,inhibit body inflammation,reduce scores of FIB-4 index and AAR,improve liver fibrosis,reduce liver stiffness,improve liver function,liver hemodynamic indexes and spleen thickness,and improve clinical efficacy.关键词
软肝化积丸/丙型肝炎肝硬化/炎症因子/肝纤维化指数/肝脏硬度/肝血流动力学Key words
Ruangan Huaji Pill/hepatitis C cirrhosis/inflammatory factors/FIB-4 index/liver stiffness/hepatic hemodynamics分类
医药卫生引用本文复制引用
刘应东,何伟,汪超,刘丹丹,耿晓源,田水林..软肝化积丸对瘀血内结型丙型肝炎肝硬化患者纤维化指标和炎症因子的影响[J].山东中医杂志,2023,42(12):1274-1281,8.基金项目
安徽省卫生健康软科学研究项目(编号:AHWJ2020a029) （编号:AHWJ2020a029）
