山东中医杂志2023，Vol.42Issue(12)：1282-1287,6.DOI:10.16295/j.cnki.0257-358x.2023.12.007
基于气机升降理论探讨哮喘共病焦虑/抑郁免疫失衡和肠道内稳态失调
Discussion on Asthma Comorbid Anxiety/Depression Immune Imbalance and Intestinal Homeostasis Disorder Based on Theory of Ascending and Descending of Qi Movement
摘要
Abstract
Objective:To investigate the differences of CD4+T lymphocytes,gastrointestinal symptoms(GSRS score),asthma control(ACT score)between asthmatic patients with comorbid anxiety/depression and those without anxiety/depression based on the theory of ascending and descending of qi movement,and the distribution of three yin and three yang constitution,so as to provide a new direction for improving asthma control.Methods:A total of 101 patients with asthma from September 2020 to December 2021 were included.Clinical data were collected,and quantity and proportion of perimeter blood immune cell helper T cell-1(Th1),helper T cell-2(Th2),helper T cells 17(Th 17),regulatory T cells(Tregs)were record,and ACT score,GSRS score,self-evaluation of anxiety scale(SAS),self-evaluation of depression scale(SDS)and three yin and three yang constitution scale score were measured for the study.According to SAS and SDS scores,patients were divided into anxiety/depression group(observation group,49 patients)and non-anxiety/depression group(control group,52 patients),to analyze the differences of each index and constitution between the two groups.Results:The scores of Th1,Th17,Th17/Treg and GSRS in the observation group were higher than those in the control group(P＜0.05),ACT score was lower in the observation group than that of the control group(P＜0.05).GSRS score was positively correlated with Th1,Th1/Th2,Th17 and Th 17/Treg(P＜0.05),while GSRS score was negatively correlated with ACT score(P＜0.05).On body constitution distribution,there were 57 patients with jueyin constitution(30 patients in observation group),23 patients with shaoyang constitution(14 patients in observation group),19 patients with yangming constitution(5 patients in observation group),1 patients with taiyang constitution(0 patient in observation group)and 1 patients with shaoyin constitution(0 patients in observation group).There was no significant difference in the ratio of anxiety/depression among 3 groups of jueyin shaoyang and yangming(P＞0.05),while the female patients with asthma usually showed shaoyang constitution(P＜0.05).Conclusions:Disorder of qi's ascending and descending was closely related to the incidence of asthma,anxiety/depression,intestinal homeostasis and immune imbalance.Patients with asthma had a high incidence of anxiety/depression,with high incidence in constitutions of jueyin,shaoyang and yangming.The immune imbalance was more serious and the treatment effect for asthma was worse in patients with anxiety/depression and severe gastrointestinal symptoms.Regulating qi movement should be an important part of relieving asthma symptoms and anxiety/depression to maintain intestinal homeostasis.关键词
哮喘/焦虑/抑郁/CD4+T淋巴细胞/肠道内稳态/三阴三阳体质/气机升降Key words
asthma/anxiety and depression/CD4+T lymphocytes/intestinal homeostasis/three yin and three yang constitution/ascending and descending of qi movement分类
医药卫生引用本文复制引用
孟子霞,李杰,黄明明,于子洋..基于气机升降理论探讨哮喘共病焦虑/抑郁免疫失衡和肠道内稳态失调[J].山东中医杂志,2023,42(12):1282-1287,6.基金项目
第七批全国老中医药专家学术经验继承工作项目,第五批全国临床优秀人才研修项目(批文号:国中医药人教函[2022]1号) （批文号:国中医药人教函[2022]1号）
