山东中医杂志2023，Vol.42Issue(12)：1288-1294,7.DOI:10.16295/j.cnki.0257-358x.2023.12.008
益肾活血解毒汤联合VRD方案治疗多发性骨髓瘤临床研究
Clinical Study on Treatment of Multiple Myeloma with Yishen Huoxue Jiedu(益肾活血解毒汤)Decoction Combined with VRD Regimen
摘要
Abstract
Objective:To explore the effectiveness and safety of Yishen Huoxue Jiedu Decoction(益肾活血解毒汤)combined with bortezomib,lenalido-mide,dexamethasone(VRD)regimen in the treatment of multiple myeloma under the guidance of the"medullary toxicity"theory.Methods:Totally,126 patients with multiple myeloma were included and randomly divided into research group and control group according to random number table method,63 patients in each group,using random number table method.The control group was treated with standard VRD chemotherapy regimen,while the research group was treated with Yishen Huoxue Jiedu Decoction besides the treatment in the control group.The total effective rate,deep remission rate,disease control rate,immune and biochemical indicators[bone marrow plasma cell ratio,serum M protein level,β2 microglobulin(β2-MG),and lactate dehydrogenase(LDH)],traditional Chinese medicine(TCM)syndrome score,life quality score and safety in both groups were compared before and after treatment.Results:After treatment,the total effective rate and deep remission rate of the research group were significantly better than those of the control group(P＜0.05).After treatment,plasma cell ratio,M proteinβ Both 2-MG and LDH improved compared to before treatment,and the difference between groups was statistically significant(P＜0.05).The efficacy scores of two groups of traditional Chinese medicine syndromes,as well as the quality of life score,showed significant improvement after treatment compared to before.The difference between the groups was statistically significant(P＜0.05).The research group had low incidence of adverse reactions(P＜0.05).Conclusions:Under the guidance of the theory of"medullary toxicity",combination of Yishen Huoxue Jiedu Decoction and VRD regimen can significantly improve the symptoms of patients with multiple myeloma,increase the overall remission rate,increase the depth of remission,reduce tumor burden,reduce chemotherapy adverse reactions,and thereby improve the life quality of patients,with good effect for tonifying healthy qi,increasing effectiveness and reducing toxicity.关键词
多发性骨髓瘤/益肾活血解毒汤/髓毒理论/化疗/VRD方案/M蛋白/中医证候积分Key words
multiple myeloma/Yishen Huoxue Jiedu Decoction/chemotherapy/VRD regimen/M protein/syndrome score/integrated Chinese and western medicine分类
医药卫生引用本文复制引用
李迎巧,高二超,王凤林,王茂生,范华,周振环,周玉才,杨淑莲..益肾活血解毒汤联合VRD方案治疗多发性骨髓瘤临床研究[J].山东中医杂志,2023,42(12):1288-1294,7.基金项目
全国名老中医药传承工作室建设项目(批文号:国中医药人教函[2022]75号) （批文号:国中医药人教函[2022]75号）
第五批全国中医临床优秀人才研修项目(批文号:国中医药人教函[2022]1号) （批文号:国中医药人教函[2022]1号）
河北省中医药管理局中医药类科研计划项目(编号:2020440) （编号:2020440）
