山东医药2023，Vol.63Issue(35)：5-9,5.DOI:10.3969/j.issn.1002-266X.2023.35.002
子宫内膜癌患者外周血红细胞膜脂肪酸组分变化及其与发病风险的关系
Changes of fatty acids levels in peripheral blood erythrocyte membrane and their relationships with the risk of endometrial cancer
摘要
Abstract
Objective To explore the changes of fatty acids levels in peripheral blood erythrocyte membrane and their relationships with the risk of endometrial cancer(EC).Methods Peripheral blood of fasting 91 EC patients(EC group)and 203 healthy volunteer women(control group)were collected.After erythrocyte cells were isolated,the levels of erythrocyte membrane fatty acids were detected by gas chromatograph-mass spectrum.The effect of changes of fatty acid levels on the risk of EC was analyzed.Results The compositions of fatty acids ranged from high level to low level in erythrocyte membrane of the EC group and control group were total saturated fatty acids(SFA),total polyunsaturated fatty acids(PUFA)and total monounsaturated Fatty Acids(MUFA).Compared with the control group,the total SFA level was higher and the total MUFA level was lower than those of the EC group(both P＜0.05),but there was no significant differ-ence in the PUFA level between these two groups(P＞0.05).In SFA of the erythrocyte membrane,the levels of myristic acid C14:0,stearic acid C18:0,behenic acid C22:0 and lignoceric acid C24:0 in the EC group were higher than those of the control group,but the level of arachidic acid C20:0 was lower than that of the control group(all P＜0.05).In MUFA of the erythrocyte membrane,the levels of palmitoleic acid C16:1n7 and nervonic acid C24:1n9 were higher,but the level of oleic acid C18:1n9 was lower than those of the control group(all P＜0.05).In ω-6 PUFA of the erythrocyte membrane,the level of linoleic acid(LA)C18:2n6 was lower,but the levels of gamma-linoleic acid(GLA)C18:3n6,C20:2n6 and C20:3n6 were higher than those of the control group(all P＜0.05).In ω-3 PUFA of erythrocyte membrane,the level of α-linolenic acid(ALA)C18:3n3 was lower,but the ratio of arachidonic acid(AA)/docosahexaenoic acid(DHA)was higher than those of the control group(both P＜0.05).As shown by binary Logistic regression analysis,the increased lev-els of total SFA,myristic acid C14:0,behenic acid C22:0,lignoceric acid C24:0,palmitoleic acid C16:1n7,nervonic acid C24:1n9,and GLA increased the risk of EC(OR= 2.14,2.36,2.60,3.21,3.25,4.81 and 2.74,respectively;all P＜0.05).Decreased levels of C20:0,C18:1n9,LA and ALA increased the risk of EC(OR=0.38,0.34,0.21 and 0.51,respectively;all P＜0.05).Conclusions The proportions of total SFA,myristic acid,behenic acid,lignoceric acid,palmitoleic acid C16:1n7,nervonic acid C24:1n9 and GLA increased in the EC patients,the proportions of arachid-ic acid C20:0,oleic acid C18:1n9,LA,and ALA decreased,and the changes in the above fatty acid proportions were re-lated to the incidence of EC.关键词
脂肪酸组分/肉豆蔻酸/山俞酸/花生酸/红细胞膜/子宫内膜癌Key words
fatty acid composition/Myristic acid/Behenic acid/Arachidic acid/erythrocyte membrane struc-ture/endometrial carcinoma分类
医药卫生引用本文复制引用
李杰萍,邹建平,江絮萍,谢榕..子宫内膜癌患者外周血红细胞膜脂肪酸组分变化及其与发病风险的关系[J].山东医药,2023,63(35):5-9,5.基金项目
福建省自然科学基金资助项目(2016J01405). （2016J01405）
