食管疾病2023，Vol.5Issue(4)：241-249,9.DOI:10.15926/j.cnki.issn2096-7381.2023.04.001
环状RNA在食管癌诊断和预后中的研究进展
Research Progress of CircRNA in Diagnosis and Prognosis of Esophageal Cancer
摘要
Abstract
Circular RNA(circRNA)is a novel endogenous circular structured non-coding RNA,which is regulated by cis-acting elements and related proteins in trans by a"back-splicing"mechanism.CircRNA plays an important role in gene splicing,transcription,chromatin modification,miRNA sponge action and protein capture.CircRNA are highly stable and differentially expressed in different tissues.CircRNA aberrant expression is associated with tumourigenesis and metastasis.However,circRNAs with important functions in esophageal cancer and their mechanisms of action are still unclear.In this paper,we review the role of circRNA in the development of esophageal cancer and its research progress as a diagnostic and prognostic marker of esophageal cancer,taking into account the functional characteristics of circRNA.关键词
食管癌/环状RNA/分子标志物Key words
esophageal cancer/circRNA/biomarker分类
医药卫生引用本文复制引用
马丽霞,左志向,石林林,李佳怡,喻莹,谷变利,鲁智豪,高社干..环状RNA在食管癌诊断和预后中的研究进展[J].食管疾病,2023,5(4):241-249,9.基金项目
河南省医学科技攻关省部共建重点项目(SBGJ202102199)河南省重点研发与推广专项(科技攻关)项目(22210231010115)洛阳市社会发展专项医疗卫生重点项目(2101038A) （SBGJ202102199）
