食管疾病2023，Vol.5Issue(4)：255-259,5.DOI:10.15926/j.cnki.issn2096-7381.2023.04.003
循环microRNAs作为潜在食管癌标志物诊断价值的Meta分析
Meta Analysis of Diagnostic Value of Circulating MicroRNAs as Potential Biomarkers for Esophageal Cancer
张嘉诚 1高雅 1孔德九 1胡晓辰 1柳颖 1申深 1张杰冲 1原翔 1王新帅1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院,中国洛阳,471003
- 折叠
摘要
Abstract
Objective To evaluate the diagnostic accuracy of circulating microRNAs in the detection of esophageal cancer.Methods A systematic literature search was conducted on relevant studies in English databases(Embase,Pubmed,Cochrane)and Chinese databases(CNKI,Wanfang,Weipu)until April 21,2022.OpenMetaAnalyst and RevMan5.3 software packages were used for statistical analysis.A bivariate ran-dom effects model(BRM)was used to comprehensively evaluate the overall microRNAs detection perform-ance,including the analysis of sensitivity and specificity parameters.Subgroup analysis was used to evaluate the heterogeneity,and sensitivity analysis was used to evaluate the robustness of the analysis.The Deeks fun-nel plot asymmetry test was used to evaluate the publication bias of the selected studies.Results 10 articles including 15 studies were included in this study,including 995 cases of esophageal cancer and 612 cases in the control group.The overall sensitivity and specificity were 0.838(95％CI:0.782～0.882)and 0.780(95％CI:0.691～0.848),respectively.The overall diagnostic odds ratio(DOR),positive likelihood ratio(PLR),and negative likelihood ratio(NLR)were 22.532(95％CI:12.237-41.487),3.598(95％CI:2.622-4.937),and 0.185(95％CI:0.121-0.283),respectively.According to the re-search design and microRNAs spectrum analysis of subgroups,it was found that multiple microRNAs panels were more accurate in detecting esophageal cancer,with a combined DOR of 30.428(95％CI:8.58-105.37).Conclusion Circulating microRNAs may serve as non-invasive detection biomarkers in the diag-nosis of esophageal cancer.When multiple microRNAs kits can be used for clinical diagnosis,they may be-come a screening tool in clinical practice.关键词
microRNA/食管癌/诊断/多miRNA盒/Meta分析Key words
microRNAs/esophageal cancer/diagnosis/multiple microRNAs panels/Meta-analysis分类
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张嘉诚,高雅,孔德九,胡晓辰,柳颖,申深,张杰冲,原翔,王新帅..循环microRNAs作为潜在食管癌标志物诊断价值的Meta分析[J].食管疾病,2023,5(4):255-259,5.
