食管疾病2023，Vol.5Issue(4)：263-268,6.DOI:10.15926/j.cnki.issn2096-7381.2023.04.005
食管鳞癌免疫治疗相关基因鉴定
Identification of Immunotherapy-Related Genes in Esophageal Squamous Cell Carcinoma
任婧 1王登奎 1杨瑞娜 1袁小志 1刘志伟 1王新帅1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院,中国洛阳,471003
- 折叠
摘要
Abstract
Objective To identify the immune genes related to the occurrence and development of esoph-ageal squamous cell carcinoma(ESCC)through tumor immune infiltration analysis of the gene expression profile.Methods Methods The gene chip expression data of GSE20347 ESCC were analyzed based on clusterProfiler algorithm and tumor-related database.Results 15 immune-related pathways and hub genes were obtained through gene set enrichment analysis(GSEA).Immune infiltration analysis suggested that there were correlation between the expression levels of various immune cells and hub genes.Conclusion AT-AD5,ATM,EHMT2,PTPN14,UTP18 and their significantly related immune cells may provide a theoretical basis for the study of ESCC immunity.关键词
食管鳞癌/免疫浸润/生存预后Key words
esophageal squamous cell carcinoma/immune infiltration/survival prognosis分类
医药卫生引用本文复制引用
任婧,王登奎,杨瑞娜,袁小志,刘志伟,王新帅..食管鳞癌免疫治疗相关基因鉴定[J].食管疾病,2023,5(4):263-268,6.
