食管疾病2023，Vol.5Issue(4)：279-284,6.DOI:10.15926/j.cnki.issn2096-7381.2023.04.008
靶向免疫代谢改善肿瘤微环境
Targeting Immune Metabolism to Improve the Tumor Microenvironment
刘谷一 1周宏祎 1丁剑兰 1陈乐乐 1孙江涛1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院,肿瘤医院,省部共建食管癌防治国家重点实验室,河南省微生态与食管癌防治重点实验室,河南省肿瘤表观遗传重点实验室,中国洛阳,471003
- 折叠
摘要
Abstract
The growing field of immune metabolism has revealed promising indications for metabolic tar-gets to modulate anti-cancer immunity.Oncogene-driven changes in tumor cell metabolism can impact the TME to limit immune responses and present barriers to cancer therapy.These changes also reveal opportunities to reshape the TME by targeting metabolic pathways to favor immunity.Here we explore current strategies that shift immune cell metabolism to pro-inflammatory states in the TME and highlight the need of better replicate physiologic conditions to select targets,clarify mechanisms,and optimize metabolic inhibitors.关键词
免疫代谢/肿瘤微环境/食管癌/免疫治疗Key words
immune metabolism/tumor microenvironment/esophageal cancer/immunotherapy分类
医药卫生引用本文复制引用
刘谷一,周宏祎,丁剑兰,陈乐乐,孙江涛..靶向免疫代谢改善肿瘤微环境[J].食管疾病,2023,5(4):279-284,6.
