有色金属材料与工程2023，Vol.44Issue(6)：18-35,18.DOI:10.13258/j.cnki.nmme.2023.06.003
用于软骨下骨修复的镁基支架
Magnesium-based scaffolds for subchondral bone regeneration
摘要
Abstract
Osteoarthritis(osteoarthritis,OA)is a degenerative disease that can lead to disability,often affecting subchondral bone.Damaged articular cartilage and subchondral bone remain challenging to heal independently,and scaffolds for tissue regeneration are a promising therapeutic method.Recently,Magnesium alloys have been considered as promising candidates for biodegradable porous scaffolds due to their good mechanical and biological properties.However,there is still no consensus on the structural design and optimization of magnesium-based scaffolds suitable for subchondral bone regeneration.Therefore,this review summarizes the research progress of magnesium alloys used for osteochondral scaffolds,including fabrication methods of porous scaffolds,optimization strategies involving alloying elements and surface modifications,parametric and non-parametric structural design,degradation,mechanical and biological properties of magnesium-based scaffolds and their influencing factors.Also,this paper discussed the potential directions of future research,intending to provide references for the development and clinical applications of porous magnesium-based scaffolds.关键词
镁基支架/软骨下骨/骨组织工程Key words
magnesium-based scaffold/subchondral bone/bone tissue engineering分类
金属材料引用本文复制引用
周茉,徐翔,王天畅,强磊,张昌入,杨涵,刘朝宗,王金武..用于软骨下骨修复的镁基支架[J].有色金属材料与工程,2023,44(6):18-35,18.基金项目
国家重点研发计划资助项目(2022YFA1207500) （2022YFA1207500）
国家自然科学基金资助项目(82072412和 92048205) （82072412和 92048205）
临港实验室"求索杰出青年计划"开放课题(LGQS-202206-04) （LGQS-202206-04）
上海交通大学医学院生物材料与再生医学研究院联合攻关项目(2022LHBO8) （2022LHBO8）
