上海针灸杂志2023，Vol.42Issue(12)：1240-1246,7.DOI:10.13460/j.issn.1005-0957.2023.12.1240
针刺联合中药治疗缺血性卒中后认知障碍的疗效观察
Therapeutic observation of acupuncture combined with Chinese medicine for cognitive impairment after ischemic stroke
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture combined with oral administration of Zi Yin Tong Luo Tang in treating cognitive impairment after ischemic stroke and investigate its effects on cerebral hemodynamics and the levels of amyloid β-protein 1-42(Aβ1-42),insulin-like growth factor 1(IGF-1),platelet endothelial cell adhesion molecule-1(PECAM-1),and tau protein.Method Ninety patients with cognitive impairment after ischemic stroke were divided into a joint group and a control group using the random number table method,with 45 cases in each group.The control group took Zi Yin Tong Luo Tang orally,and the joint group received acupuncture combined with oral administration of Zi Yin Tong Luo Tang.The China stroke scale(CSS),Montreal cognitive assessment(MoCA),functional comprehensive assessment(FCA),and modified Barthel index(MBI)scores in the two groups were observed before and after the treatment.The mean blood flow velocity,peak blood flow,and vascular resistance index of cerebral arteries were also monitored before and after the intervention.The levels of pentraxin 3(PTX3),vascular cell adhesion molecule-1(VCAM-1),IGF-1,PECAM-1,Aβ1-42,complement C1q tumor necrosis factor-related protein 9(CTRP9),soluble CD40 ligands(sCD40L),and tau protein were compared before and after the treatment.The clinical efficacy was also compared between the two groups.Result The joint group had a higher total effective rate than the control group(P＜0.05).After the treatment,the MoCA,FCA,and MBI scores were higher in the joint group than in the control group(P＜0.05),and the CSS score was lower in the joint group(P＜0.05).After the intervention,the cerebral artery resistance index was lower in the joint group than in the control group(P＜0.05),and the mean blood flow velocity and peak blood flow were higher in the joint group(P＜0.05).The contents of CTRP9,Aβ1-42,and IGF-1 were higher in the joint group than in the control group after the treatment(P＜0.05),and the VCAM-1,PTX-3,sCD40L,PECAM-1,and tau protein were lower in the joint group(P＜0.05).Conclusion Acupuncture combined with oral Zi Yin Tong Luo Tang can improve neurological function,cognitive function,daily living activities,and cerebral artery hemodynamics in treating patients with cognitive impairment after ischemic stroke,producing more significant efficacy than oral Zi Yin Tong Luo Tang alone.Further,this method can inhibit inflammatory responses and regulate the levels of Aβ1-42,IGF-1,PECAM-1,and tau protein.关键词
针刺疗法/针药并用/脑梗死/中风后遗症/认知障碍/痴呆,血管性/神经功能Key words
Acupuncture therapy/Acupuncture medication combined/Cerebral infarction/Post-stroke sequelae/Cognitive impairment/Dementia,Vascular/Neurological function分类
医药卫生引用本文复制引用
黑丹丹,吴冠瑾,冯静静,马勇,任凯亮..针刺联合中药治疗缺血性卒中后认知障碍的疗效观察[J].上海针灸杂志,2023,42(12):1240-1246,7.基金项目
河南省中医药科学研究专项课题(22-10ZY1020) （22-10ZY1020）
