上海针灸杂志2023，Vol.42Issue(12)：1253-1258,6.DOI:10.13460/j.issn.1005-0957.2023.12.1253
电针联合中药治疗血管性痴呆的疗效观察及对认知功能和脑血流动力学的影响
Observation of the therapeutic effect of electroacupuncture combined with Chinese medicine in the treatment of vascular dementia and its effect on cognitive function and cerebral hemodynamics
摘要
Abstract
Objective To observe the clinical efficacy of electroacupuncture combined with Qi Shen Huan Wu capsule in the treatment of vascular dementia of intertwined phlegm and blood stasis pattern,and to observe its effect on cognitive function and cerebral hemodynamics.Method Ninety-six patients with vascular dementia of intertwined phlegm and blood stasis pattern were randomly divided into three groups(group A,group B and group C),with 32 cases in each group.Group A was given oral Cytarabine capsule,group B was given Qi Shen Huan Wu capsule in addition to the treatment used in group A,and group C was given electroacupuncture in addition to the treatment used in group B.The clinical efficacy and the occurrence of adverse effects of the three groups were compared.The scores of mini mental state examination(MMSE)and activity of daily living(ADL)were observed before and after the treatment of the three groups.The changes of cerebral hemodynamic indexes(peak systolic and diastolic velocities of the middle cerebral artery)and serum brain damage indexes[central nervous system specific protein β(S-100β)and neuron-specific enolase(NSE)]were observed before and after the treatment of the three groups.Result The total effective rate of group C was 93.8%,which was higher than that of group B(75.0%)and group A(50.0%)(P＜0.05).The total effective rate of group B was higher than that of group A(P＜0.05).After treatment,the differences among the three groups in MMSE and ADL scores,peak systolic and diastolic velocities of the middle cerebral artery,and serum S100β and NSE levels were statistically significant(P＜0.05);MMSE and ADL scores,peak systolic and diastolic velocities of the middle cerebral artery,and serum S100β and NSE levels of group C were superior to those of group A and B(P＜0.05);there was an interaction between time and group effect(P＜0.05).Conclusion In addition to oral administration of Cytarabine capsules,the clinical efficacy of electroacupuncture combined with Qi Shen Huan Wu capsule in the treatment of vascular dementia of intertwined phlegm and blood stasis pattern was better than that of oral administration alone,and it could improve the cognitive function and daily life ability of the patients,as well as improve the haemodynamic indexes of the middle cerebral artery and the level of serum brain damage indexes.关键词
电针/针药并用/痴呆,血管性/痰瘀互结型/认知功能/血液流变学Key words
Electroacupuncture/Acupuncture and medication combined/Dementia,Vascular/Intertwined phlegm and blood stasis pattern/Cognitive function/Hemorheology分类
医药卫生引用本文复制引用
王树峰,崔友祥,霍飞飞,胡方梅,王世信,刘国华..电针联合中药治疗血管性痴呆的疗效观察及对认知功能和脑血流动力学的影响[J].上海针灸杂志,2023,42(12):1253-1258,6.基金项目
河北省中医药管理局中医药类科研计划项目(2021333) （2021333）
