上海针灸杂志2023，Vol.42Issue(12)：1269-1276,8.DOI:10.13460/j.issn.1005-0957.2023.12.1269
督灸联合龟鹿胶治疗重症肌无力的疗效观察
Therapeutic observation of Governor Vessel moxibustion plus Gui Lu Jiao in treating myasthenia gravis
摘要
Abstract
Objective To observe the clinical efficacy of Governor Vessel moxibustion plus oral administration of Gui Lu Jiao in treating myasthenia gravis(MG).Method Eighty-four MG patients were randomized into a control group(41 cases)and an observation group(43 cases).The control group received oral Prednisone acetate for treatment,and the observation group received Governor Vessel moxibustion and oral administration of Gui Lu Jiao.Before and after the intervention,the myasthenia gravis muscular endurance scale(MGMES)score,Medical Research Council(MRC)muscle strength scale score,limb skeletal muscle index,and myoelectrophysiological indicators of orbicularis oculi fibers were observed for both groups.The serum levels of T cell subsets(CD4+,CD8+,and CD4+/CD8+),immune indicators[immunoglobulin A(IgA),immunoglobulin M(IgM),and immunoglobulin G(IgG)],and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-8(IL-8)]were also detected before and after the treatment.The clinical efficacy and adverse reactions were compared between the two groups.Result The total effective rate was 95.3%,69.7%,and 51.2%in the observation group after treatment and at the 6-month and 12-month follow-ups,respectively,higher than 75.6%,46.3%,and 26.8%in the control group(P＜0.05).After the treatment,the MGMES score and myoelectrophysiological indicators of orbicularis oculi fibers were lower in the observation group than in the control group(P＜0.05);the MRC muscle force scale score and limb skeletal muscle index were higher in the observation group than in the control group(P＜0.05).After the intervention,the levels of CD4+,CD4+/CD8+,TNF-α,IL-4,and IL-10 in the observation group were lower than those in the control group(P＜0.05),and the levels of CD8+,IgA,IgM,and IgG were higher in the observation group(P＜0.05).The observation group had an adverse reaction rate of 2.3%,which was lower than 34.1%in the control group(P＜0.05).Conclusion Governor Vessel moxibustion plus oral administration of Gui Lu Jiao can produce more significant clinical efficacy than oral Prednisone acetate in treating MG.This method can enhance muscle stamina and strength and improve the levels of T cell subsets,immune indicators,and inflammatory factors in the patients.关键词
灸法/铺灸/督灸/重症肌无力/肌力/T淋巴细胞亚群/免疫/炎性因子Key words
Moxibustion/Long-snake moxibustion/Governor Vessel moxibustion/Myasthenia gravis/Muscle strength/T cell subsets/Immunity/Inflammatory factors分类
医药卫生引用本文复制引用
郭瑞,边丽,陈瑞华,王玲,杨俊红,李勤..督灸联合龟鹿胶治疗重症肌无力的疗效观察[J].上海针灸杂志,2023,42(12):1269-1276,8.基金项目
河南省中医药管理局项目(20-21ZY1044) （20-21ZY1044）
