世界中医药2023，Vol.18Issue(20)：2998-3003,6.DOI:10.3969/j.issn.1673-7202.2023.20.026
黄芪多糖免疫调节和抗肿瘤作用机制研究新进展
Recent Advances in the Study of the Immunomodulatory and Antitumor Mechanisms of Astragalus Polysaccharides
摘要
Abstract
Astragalus polysaccharides(APS),as the main active component of Astragalus,has attracted increasing attention be-cause of its important role in anti-tumor process.The dual roles of tumor-associated neutrophils(TANs)in promoting and inhibiting tumorigenesis and development has become a hotspot in the field of oncology research.By investigating and summarizing the dual roles of APS in promoting the anti-tumor effects of TANs and inhibiting the pro-tumor effects,this paper reviewed the related litera-tures,analyzed the mechanisms of inhibiting angiogenesis,protein hydrolysis,regulating the expression of relevant cytokines,modu-lating the cell cycle and apoptosis processes,and outlines the research progress of related traditional Chinese herbs in promoting the anti-tumor effects of TANs,providing theoretical support for further clarifying its relevant mechanisms and development status.关键词
黄芪/黄芪多糖/免疫调节/肿瘤相关中性粒细胞/抗肿瘤/肿瘤细胞凋亡/综述Key words
Astragalus/Astragalus Polysaccharides/Immunomodulation/Tumor-Associated Neutrophils/Anti-tumor/Tumor Cell Apoptosis/Review分类
中医学引用本文复制引用
虞跃跃,俞瑶帅,汪铱宇,崔建美,孙欢,孟成鑫,李云霞,朱延继..黄芪多糖免疫调节和抗肿瘤作用机制研究新进展[J].世界中医药,2023,18(20):2998-3003,6.基金项目
国家科技部对发展中国家科技援助项目(KY201904005)——中-匈合作中药培植基地建设与中药产品开发 （KY201904005）
河北省中医药联合基金重点项目(H2022209068)-miRNA-139-5p/Notch通路对哮喘大鼠脊髓间充质干细胞归巢的影响及针刺干预的机制 （H2022209068）
国家级大学生创新创业训练计划项目(X2020012)——甘草多糖的免疫调节抗肿瘤作用及机制研究 （X2020012）
河北省省属高校基本科研业务费项目(JQN2021034)——乌头注射液对大鼠膝骨性关节炎的作用及其机制研究 （JQN2021034）
唐山市科技创新团队培养计划项目(18130204B)——唐山市针灸辨体质治未病基础创新团队 （18130204B）
