生命科学仪器2023，Vol.21Issue(3)：1-11,11.DOI:10.11967/2023210601
胶质细胞:神经退行性疾病未来治疗的潜在靶点
Glial cells:Potential targets for future treatment of neurodegenerative diseases
摘要
Abstract
Neurodegenerative diseases,including Alzheimer's disease(AD)and Parkinson's disease(PD),are char-acterized by progressive loss and death of the structure and function of neurons in the central nervous system.Glial cells account for about half of the cells in the central nervous system(CNS).They are the dynamic guardians of the formation and maintenance of the CNS and play an important role in the regulation of neurodegenerative diseases.With the emergence and maturation of single cell sequencing technology,disease-related glial cell heterogeneity appears,providing a new therapeutic target for the treatment of neurodegenerative diseases.This review mainly summarizes the functions of steady-state and non-steady-state glial cells in the brain,and explores disease-re-lated glial cells in neurodegenerative diseases based on single-cell sequencing technology,providing new ideas for the treatment of neurodegenerative diseases.关键词
神经退行性疾病/阿尔兹海默症/帕金森疾病/单细胞测序/胶质细胞异质性Key words
Neurodegenerative diseases/Alzheimer's disease/Parkinson's disease/Single cell sequencing/Hetero-geneity of glial分类
信息技术与安全科学引用本文复制引用
王晗,陈姿喧,邓玉林..胶质细胞:神经退行性疾病未来治疗的潜在靶点[J].生命科学仪器,2023,21(3):1-11,11.基金项目
国家自然科学基金青年基金项目(81601114) （81601114）
