生命科学仪器2023，Vol.21Issue(3)：73-79,7.DOI:10.11967/2023210611
经颅磁声电刺激对皮层锥体神经元的突触传递特性影响的仿真分析
Simulation analysis of the effect of transcranial magnetoacoustic-electrical stimulation on STP in cortical pyramidal neurons
李子春 1张帅 1赵清扬 1徐亦豪 1武健康 1徐桂芝1
作者信息
- 1. 省部共建电工装备可靠性与智能化国家重点实验室河北工业大学,天津 300130||河北省电磁场与电器可靠性重点实验室河北工业大学,天津 300130
- 折叠
摘要
Abstract
short term synaptic plasticity(STP)is characterized by rapidity and frequency.It is the key to the storage process in working memory to process information and select neuronal clusters in brain memory activities in a varie-ty of ways.Transcranial Magneto-acoustic-electrical Stimulation(TMAES),as a new non-invasive means of ultrasound and static magnetic field coupling for brain regulation,has a potential role in regulating the electrical ac-tivity of normal and pathological biological tissues.This paper aims to study the effects of TMAES on the specific mechanism of synaptic STP in cortical pyramidal neurons,and explore the changes of presynaptic calcium concen-tration,vesicle release and postsynaptic potential in cortical pyramidal neurons under different stimulus current in-tensities by building a synaptic transmission model of cortical pyramidal neurons.The results showed that with the increase of stimulating current intensity,the change frequency and amplitude of intracellular calcium concentration increased significantly,and the total amount of vesicle release increased.However,STP tended to weaken during the stimulation time,but changed from stable enhancement to first enhancement and then inhibition during single cluster discharge with the increase of stimulation current.The results are helpful to promote the research on the dy-namics of TMAES subcortical working memory network,and provide important reference value and research sig-nificance for further research on the effects of transcranial magnetoacoustic stimulation on working memory in rats.关键词
经颅磁声电刺激/短时程突触可塑性/锥体神经元突触/突触后电位/钙依赖可塑性Key words
TMAES/STP/pyramidal neuron synapse/postsynaptic potential/calcium dependent plasticity分类
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李子春,张帅,赵清扬,徐亦豪,武健康,徐桂芝..经颅磁声电刺激对皮层锥体神经元的突触传递特性影响的仿真分析[J].生命科学仪器,2023,21(3):73-79,7.
