生命科学仪器2023，Vol.21Issue(3)：100-103,4.DOI:10.11967/2023210617
miR-192-5p和miR-22-3p在痛风性关节炎患者中的表达水平及调节机制
Expression and regulation mechanism of miR-192-5p and miR-22-3p in patients with gouty arthritis
安丽欣 1张倩 1李昆 1刘耔序1
作者信息
- 1. 秦皇岛市第一医院风湿免疫科,河北秦皇岛 066099
- 折叠
摘要
Abstract
Objective:To analyze the expression levels and regulatory mechanisms of serum miR-192-5p and miR-22-3p in patients with gouty arthritis.Method:65 patients with gouty arthritis and 65 healthy examinees admit-ted to Qinhuangdao First Hospital from January 2020 to December 2021 were divided into an observation group and a control group,respectively.The expression levels and relative surface area of miR-192-5p and miR-22-3p in the patients'serum were detected using real-time fluorescence quantitative PCR.The erythrocyte sedimentation rate(ESR)was measured using a hematocrit analyzer,and blood uric acid(BUA)Result:Compared with the con-trol group,the relative expression levels of miR-192-5p and miR-22-3p in the serum of the observation group patients increased(P＜0.05),ESR and BUA increased(P＜0.05),and serum TNF increased-α、IL-6,IL-1β The expression levels of IL-10 and Th1/Th2 increased(P＜0.05),.ROC curve analysis revealed that serum miR-192-5p and miR-22-3p have good diagnostic efficacy in gouty arthritis.Conclusion:Patients with gouty arthri-tis have abnormally elevated serum miR-192-5p and miR-22-3p,which may be related to inflammatory and immune responses.关键词
miR-192-5p/miR-22-3p/痛风性关节炎/调节机制Key words
miR-192-5p/miR-22-3p/Gouty arthritis/Regulatory mechanism分类
医药卫生引用本文复制引用
安丽欣,张倩,李昆,刘耔序..miR-192-5p和miR-22-3p在痛风性关节炎患者中的表达水平及调节机制[J].生命科学仪器,2023,21(3):100-103,4.
