生命科学仪器2023，Vol.21Issue(3)：104-108,5.DOI:10.11967/2023210618
软通道微创引流术对老年脑出血患者神经功能及血清氧化应激指标的影响
Effects of soft channel minimally invasive drainage on neurological function and serum oxidative stress indexes in elderly patients with cerebral hemorrhage
摘要
Abstract
Objective:To investigate the effect of soft channel minimally invasive drainage on neurological function and serum oxidative stress indexes in elderly patients with cerebral hemorrhage.Methods:The clinical treatment da-ta of 107 elderly patients with cerebral hemorrhage admitted to our hospital from July 2019 to July 2021 were retro-spectively analyzed,and they were grouped according to different surgical methods.The patients who underwent hard channel minimally invasive drainage were the control group(59 cases),and the patients who underwent soft channel minimally invasive drainage were the observation group(48 cases).Serum neuron-specific enolase(NSE),neuropeptide(NP)Y,brain-derived neurotrophic factor(BDNF),superoxide dismutase(SOD),malondialdehyde(MDA)were detected by enzyme-linked immunosorbent assay,and serum glutathione peroxidase(GSH-Px)level was detected by spectrophotometry.The neurological deficit before and after surgery was assessed by the National Institutes of Health Stroke Scale(NIHSS).Barthel index Table was used to assess pa-tients'ability of daily living before and after surgery.The serum neurological function factors,oxidative stress indi-cators,neurological deficits,daily living ability and postoperative complications were compared in two groups.Re-sults:The serum NSE and NPY levels of the two groups of patients after surgery were decreased,and the NSE and NPY in observation group was lower compared with the control group(P＜0.05).The serum SOD and GSH-Px of the two groups of patients after surgery were increased,and compared with the control group,the SOD and GSH-Px of observation group was higher(P＜0.05).The NIHSS scores of the two groups after surgery were decreased,and compared with the control group,the NIHSS score of observation group was lower(P＜0.05).The Barthel in-dex scores of the two groups were increased after surgery,and the Barthel index score of observation group was higher compared with the control group(P＜0.05).The rate of postoperative complications in the control group was significantly higher than that in the observation group(20.34%vs 4.17%)(χ2=6.087,P=0.014).Conclusion:The use of soft channel minimally invasive drainage can improve the neurological function of elderly patients with cerebral hemorrhage,reduce oxidative stress,and improve the daily living ability of patients.关键词
软通道微创引流术/脑出血/神经功能/氧化应激Key words
Soft channel minimally invasive drainage/intracerebral hemorrhage/neurological function/oxidative stress分类
医药卫生引用本文复制引用
代红,姚光伟,袁春苗,王小明,匡德利..软通道微创引流术对老年脑出血患者神经功能及血清氧化应激指标的影响[J].生命科学仪器,2023,21(3):104-108,5.基金项目
秦皇岛市重点研发计划科技支撑项目 （）
编号:202101A119项目名称:软通道颅内血肿钻孔引流术对老年性脑出血血脑屏障保护的探究 （）
