生命科学仪器2023，Vol.21Issue(3)：152-155,4.DOI:10.11967/2023210630
中性粒细胞淋巴细胞比值、脂蛋白相关磷脂酶A2与2型糖尿病伴冠心病的相关性研究
Correlation between neutrophil lymphocyte ratio,lipoprotein-associated phospholipase A2 and type 2 diabetes mellitus with coronary heart disease
张晨 1吉飞跃 1郑良凤 1颜永进 2郭宗锋3
作者信息
- 1. 江苏省海安市人民医院中心实验室,江苏海安 226600
- 2. 江苏省海安市人民医院心内科,江苏海安 226600
- 3. 江苏省海安市人民医院麻醉科,江苏海安 226600
- 折叠
摘要
Abstract
Objective:To investigate the relationship of neutrophil to lymphocyte ratio(NLR)and lipoprotein-as-sociated phospholipase A2(Lp-PLA2)with type 2 diabetes mellitus(T2DM)complicated with coronary artery disease(CAD).Methods:70 patients with T2DM who were treated in Hai'an People's Hospital from January 20,2020 to June 18,2021 were prospectively selected as the research object,and were divided into T2DM group and T2DM+CAD group according to whether CAD was combined or not,and then 35 healthy people who received physical examination in the same period were selected as the Control group.The general data and laboratory indexes of the subjects were collected,the risk factors of T2DM complicated with CAD were analyzed by multivariate Lo-gistic regression,and the predictive value of NLR and Lp-PLA2 was analyzed by ROC curve.Results:Multivariate Logistic regression analysis showed that CHR(OR=1.028),NLR(OR=9.263)and Lp-PLA2(OR=4.152)were independent risk factors for T2DM with CAD(all P＜0.05).ROC curve shows that the diagnostic efficiency of NLR and Lp-PLA2 combined prediction is high,with AUC of 0.950,sensitivity of 85.26%and specificity of 89.06%.Conclusions:NLR and Lp-PLA2 may be predictors of T2DM with CAD,and may be used to differentiate T2DM patients with CAD.关键词
中性粒细胞淋巴细胞比值/脂蛋白相关磷脂酶A2/2型糖尿病伴冠心病Key words
neutrophil to lymphocyte ratio/lipoprotein-associated phospholipase A2/type 2 diabetes mellitus complicated with coronary artery disease分类
医药卫生引用本文复制引用
张晨,吉飞跃,郑良凤,颜永进,郭宗锋..中性粒细胞淋巴细胞比值、脂蛋白相关磷脂酶A2与2型糖尿病伴冠心病的相关性研究[J].生命科学仪器,2023,21(3):152-155,4.
