生殖医学杂志2023，Vol.32Issue(12)：1813-1819,7.DOI:10.3969/j.issn.1004-3845.2023.12.008
短时受精结合早期补救ICSI的临床应用价值分析
Clinical application value of short-term fertilization combined with early rescue ICSI
摘要
Abstract
Objective:To explore the clinical application value of short-term insemination combined with early rescue intracytoplasmic sperm injection(R-ICSI). Methods:The clinical data of patients who received IVF/ICSI treatment in the Reproductive Hospital of Guangxi Zhuang Autonomous Region from January 2020 to December 2021 were retrospectively analyzed.According to the method of insemination,the patients were divided into R-ICSI group(105 cycles),conventional IVF group(2 058 cycles)and conventional ICSI group(486 cycles).There were 56 fresh transplant cycles in the R-ICSI group,1 059 fresh transplant cycles in the IVF group and 259 fresh transplant cycles in ICSI transplant cycles.The basic information,laboratory outcome,and pregnancy outcome were analyzed among the three groups. Results:In the comparison of basic information,there were no significant differences in female age,BMI,years of infertility,Gn dosage and days,basal sex hormone levels,average number of oocytes retrieved,and transplantable cycle rate among the three groups(P＞0.05).The primary infertility rate in the R-ICSI group and ICSI group was significantly higher than that in the IVF group(P＜0.05),but there was no significant difference between the R-ICSI group and ICSI group(P＞0.05).No patients in the R-ICSI group used follicular phase long protocol,while there was no significant difference in the proportion of cycles used follicular phase long protocol for ovulation induction between the IVF group and the ICSI group(P＞0.05).The proportion of cycles used luteal phase long protocol for ovulation induction was significantly higher than that of the IVF group(P＜0.05),but there was no significant difference compared to the ICSI group(P＞0.05).There was no significant difference in the proportion of cycles used super-long protocol and antagonist protocol for ovulation induction among the three groups(P＞0.05).In the comparison of laboratory outcomes,the total fertilization rate and normal fertilization rate of patients in the R-ICSI group and ICSI group were higher than those in the IVF group(P＜0.05),but the M Ⅱ rate,poly-spermy rate,high-quality embryo rate,blastocyst formation rate,and available blastocyst rate were significantly lower than those in the IVF group(P＜0.05).The total fertilization rate and poly-spermy rate of the R-ICSI group were significantly higher than those of the ICSI group(P＜0.05),while the blastocyst formation rate was significantly lower than that of the ICSI group(P＜0.05).The proportion of Day 3 embryo cycles transferred in the ICSI group was significantly higher than that in the IVF group(P＜0.05),but there was no significant difference compared to the R-ICSI group(P＞0.05).There was no significant difference in the average number of embryos transferred and the proportion of cycles with Day 5 embryo transferred among the three groups of patients(P＞0.05).In the comparison of clinical outcomes,there were no significant differences in clinical pregnancy rate,implantation rate,abortion rate,delivery rate,multiple pregnancy rate,ectopic pregnancy rate,live birth rate,sex ratio at birth and birth weight among the three groups(P＞0.05). Conclusions:Short-term fertilization combined with R-ICSI can achieve good laboratory and clinical outcomes,which has important application value for patients with failed or low fertilization rate in conventional IVF.关键词
受精失败/短时受精/早期补救ICSI/辅助生殖Key words
Fertilization failure/Short-term fertilization/Early rescue ICSI/Assisted reproduction分类
医药卫生引用本文复制引用
莫丽芬,阮秋燕,劳艳萍,王超,莫房德,钟慧芝,牛向丽..短时受精结合早期补救ICSI的临床应用价值分析[J].生殖医学杂志,2023,32(12):1813-1819,7.基金项目
广西卫生健康委自筹课题(Z-A20220366) （Z-A20220366）
