天津中医药2023，Vol.40Issue(12)：1567-1574,8.DOI:10.11656/j.issn.1672-1519.2023.12.12
中医药治疗小儿抽动秽语综合征有效性及安全性的系统评价与Meta分析
Efficacy and safety of treatment of children with Tourette's syndrome by traditional Chinese medicine:a systematic review and Meta-analysis
摘要
Abstract
[Objective]To systematically evaluate the efficacy and safety of treatment of children with Tourette's syndrome by traditional Chinese medicine.[Methods]6 databases of China National Knowledge Infrastructure(CNKI),Wanfang Data,SinoMed,PubMed,the Cochrane Library and Embase were comprehensively searched by computer to collect randomized controlled trials of treatment of children with Tourette's syndrome by traditional Chinese medicine.The retrieval time was from these databases inception to April 30,2022.RevMan 5.4.1 software was used for data analysis after independent literature screening,data extraction,and bias risk assessment according to pre-established inclusion and exclusion criterias.[Results]Finally,16 RCTs with 1 371 patients were included.Meta-analysis showed that traditional Chinese medicine in the treatment of pediatric tics can improve clinical efficacy,[OR=2.22,95%CI(1.58,3.13),P<0.01],improved the YGTSS total score[MD=-3.70,95%CI(-4.99,-2.42),P<0.01],YGTSS motor tic activity score[MD=-2.50,95%CI(-3.19,-1.81),P<0.01],YGTSS vocal tic score[MD=-1.56,95%CI(-2.38,-0.75),P<0.01],reduce the TSSS score[MD=0.08,95%CI(0.03,0.13),P<0.01],improve the ISLQ score[MD=5.30,95%CI(0.33,10.27),P<0.01],reduce the score of traditional Chinese medicine syndrome,and have good safety[OR=0.17,95%CI(0.09,0.31),P<0.01].[Conclusion]Traditional Chinese medicine in the treatment of Tourette's syndrome in children can improve clinical efficacy,improve motor tic and vocal tic symptoms,improve children's quality of life,reduce traditional Chinese medicine syndrome score.And it has good clinical safety.Due to the limitation of the quality of the included ariticles,high-quality clinical studies are needed for validation the conclusion.关键词
小儿抽动秽语综合征/系统评价/Meta分析Key words
children with Tourette's syndrome/systematic review/Meta-analysis分类
医药卫生引用本文复制引用
吴上彬,王可仪,林晓红,王辉,杜淑娟..中医药治疗小儿抽动秽语综合征有效性及安全性的系统评价与Meta分析[J].天津中医药,2023,40(12):1567-1574,8.基金项目
国家中医药管理局罗笑容全国名老中医药专家传承工作室建设项目(14GG2X02) （14GG2X02）
2021年广东省中医药管理局专项(20212066). （20212066）
