武汉工程大学学报2023，Vol.45Issue(6)：613-619,7.DOI:10.19843/j.cnki.CN42-1779/TQ.202302007
异噁唑啉类衍生物的合成与杀虫活性研究
Synthesis and Insecticidal Activity of Isoxazoline Derivatives
摘要
Abstract
To explore isoxazolines as an insecticide leads,we synthesized six new isoxazolines(G1-G6)by a seven-step reaction sequence using 3,5-dichlorophenylboronic acid,methyl 5-bromo-3-methylpicolinate,and methyl 5-bromopicolinate as starting materials.The structures of the target compounds were characterized by 1H and 13C nuclear magnetic resonance spectroscopy and high resolution mass spectrometry.We also tested their insecticidal activities against Drosophila melanogaster and Pyrausta nubilalis.The bioassay results indicate that at the mass concentration of 100 mg/L,compounds G1,G4 and G6 exhibit effective insecticidal activity against Drosophila melanogaster and Pyrausta nubilalis,while compound G4 exhibits 100.00%mortality and G1 shows over 80.00%mortality against both Drosophila melanogaster and Pyrausta nubilalis.These results can provide important information and theoretical basis for designing and developing new isoxazoline insecticides.关键词
异噁唑啉/γ-氨基丁酸/衍生物/杀虫活性Key words
isoxazoline/γ-aminobutyric acid/derivatives/insecticidal activity分类
化学化工引用本文复制引用
钱云飞,闫杰桂,宋璐璐,巨修练,刘根炎..异噁唑啉类衍生物的合成与杀虫活性研究[J].武汉工程大学学报,2023,45(6):613-619,7.基金项目
国家自然科学基金(22177090,21807082) （22177090,21807082）
湖北省教育厅科学技术研究项目(D20221503) （D20221503）
湖北省高等学校优秀中青年科技创新团队计划项目(T201908) （T201908）
湖北省中央引导地方科技发展专项资金项目(2020ZYYD040) （2020ZYYD040）
