武警医学2023，Vol.34Issue(12)：1050-1054,5.
中年良性前列腺增生患者性激素水平与胰岛素抵抗的相关性分析
Correlation between sex hormone levels and insulin resistance in middle-aged patients with benign prostatic hyperplasia
摘要
Abstract
Objective To analyze the correlation between sex hormone levels and insulin resistance in middle-aged patients with benign prostatic hyperplasia(BPH).Methods The clinical data of 135 middle-aged male patients with BPH who participated in physical examination in a top three hospital from January 2020 to December 2022 were retrospectively analyzed,and according to the level of the insulin resistance index(HOMA-IR),55 cases in the BPH insulin resistance(IR)group(HOMA-IR>2.69)and 80 ca-ses in the BPH non-IR group(HOMA-IR≤2.69)were included,respectively.General data,sex hormone indexes and glucose metab-olism indexes were compared between the two groups.The correlation between sex hormone levels and glucose metabolism indexes was analyzed.Results The levels of FBG,INS and HOMA-IR in IR group were higher than those in non-IR group,serum T and FSH lev-els were lower than those in non-IR group,E2 and E2/T levels were higher than those in non-IR group.Serum testosterone(T)showed a significant negative correlation with HbA1c(r=-0.27,P=0.002),HOMA-IR(r=-0.23,P=0.007),and serum T was negatively correlated with fasting insulin(FINS)(r=-0.20,P=0.021).Serum estradiol(E2)was positively correlated with FINS(r=0.19,P=0.023)and HOMA-IR(r=0.18,P=0.041),and E2/T was significantly positively correlated with FINS(r=0.30,P<0.001)and HOMA-IR(r=0.30,P<0.001).Serum follicle-stimulating hormone(FSH)was negatively correlated with FINS(r=-0.25,P= 0.004)and HOMA-IR(r=-0.25,P=0.004);serum prolactin was negatively correlated with fasting blood glucose(r=-0.21,P= 0.013).Conclusions Insulin resistance may be related with the levels of various sex hormones in middle-aged BPH patients,which has some clinical value for BPH prevention.关键词
良性前列腺增生/睾酮/雌二醇/胰岛素抵抗Key words
benign prostatic hyperplasia/testosterone/es-tradiol/insulin resistance分类
医药卫生引用本文复制引用
逄瑷博,吕俊刚,黄薇,凌存保,林凡丹,张春燕,田亚平..中年良性前列腺增生患者性激素水平与胰岛素抵抗的相关性分析[J].武警医学,2023,34(12):1050-1054,5.基金项目
国家重点研发计划(2021YFC2009302) （2021YFC2009302）
