外科理论与实践2023，Vol.28Issue(5)：437-440,4.DOI:10.16139/j.1007-9610.2023.05.08
大剂量静脉注射维生素C在危重症中的应用
Application of high dose intravenous vitamin C in critical cared diseases
赵冰 1虞纤纤 1毛恩强1
作者信息
- 1. 上海交通大学医学院附属瑞金医院急诊科,上海 200025
- 折叠
摘要
Abstract
Vitamin C is an essential micronutrient for human and its deficiency will lead to scurvy.In recent years,as a new therapeutic strategy,high dose intravenous vitamin C(HDIVC)has been widely studied in critical cared diseases.In this review,we summarized the progress of HDIVC in sepsis,including its research history,rationality of usage,controversy and prospect,problems and outlook.The application of HDIVC in critical cared diseases underwent three periods:early,preheating and outbreaking period.Given the reduction of vitamin C in critical diseases,it requires rapid intravenous supplementation.We confirmed the therapeutic efficacy of HDIVC in COVID-19 and severe acute pancreatitis respectively.It is well known that HDIVC has effect of suppressing inflammatory responses,stabilizing the circulation and improving the immunity.But the application of HDIVC in critical cared diseases is still controversial,for the opposing findings in multiple large-scale randomized controlled trials.Future studies should be better to pay further attention on the dose and time of vitamin C and vitamin C plasma concentration monitoring.关键词
维生素C/大剂量静脉注射维生素C/危重症Key words
Vitamin C/High dose intravenous vitamin C(HDIVC)/Critical cared disease分类
医药卫生引用本文复制引用
赵冰,虞纤纤,毛恩强..大剂量静脉注射维生素C在危重症中的应用[J].外科理论与实践,2023,28(5):437-440,4.
