外科理论与实践2023，Vol.28Issue(5)：483-487,5.DOI:10.16139/j.1007-9610.2023.05.15
CAR-T细胞免疫治疗结肠直肠癌的研究现状与展望
Current status and prospect of CAR-T cell immunotherapy for colorectal cancer
摘要
Abstract
Chimeric antigen receptor T(CAR-T)cell therapy is a new method of immunotherapy for cancer that has achieved remarkable results in treating blood tumors.However,colorectal cancer(CRC),as a solid tumor,has different characteristics from hematological tumors,which impose certain constraints on the selection of its therapeutic targets and the effectiveness of treatment of CAR-T therapy.Therefore,it is necessary to select therapeutic targets with high specificity and effectiveness according to the characteristics of CRC,as well as to break through the constraints such as adverse effects caused by the treatment and the solid tumor microenvironment,to make CAR-T therapy applicable in the treatment of CRC.This article aimed to summarize the strategy of selecting therapeutic targets for CAR-T cell immunotherapy for CRC,analyze the restrictive factors of this therapy in the treatment of CRC,and forecast the prospect of CAR-T cell immunotherapy for CRC.关键词
嵌合抗原受体T细胞/结肠直肠癌/免疫治疗Key words
Chimeric antigen receptor T cell/Colorectal cancer/Immunotherapy分类
医药卫生引用本文复制引用
张天帅,周乐其,于冠宇,张卫..CAR-T细胞免疫治疗结肠直肠癌的研究现状与展望[J].外科理论与实践,2023,28(5):483-487,5.基金项目
上海申康医院发展中心第二轮《促进市级医院临床技能与临床创新三年行动计划》研究型医师创新转化能力培训项目(SHDC2022CRT007) （SHDC2022CRT007）
