Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of NanozymesOACSTPCD
Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of Nanozymes
Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advan-tages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale production.Recently,with the cross fusion of nanomedicine and nanoca-talysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side effects.Thus,various nanozymes have been developed and used for tumor therapy.In this review,more than 270 research articles are discussed systematically to present progress in the past five years.First,the discovery and development of nanozymes are summarized.Second,classification and catalytic mechanism of nanozymes are discussed.Third,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical design.Then,synergistic theranostic strategy of nanozymes are introduced.Finally,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mecha-nism,predicting and evaluating activities.
Lu Yang;Shuming Dong;Shili Gai;Dan Yang;He Ding;Lili Feng;Guixin Yang;Ziaur Rehman;Piaoping Yang
Key Laboratory of Superlight Materials and Surface Technology,Ministry of Education,College of Materials Science and Chemical Engineering,Harbin Engineering University,Harbin 150001,People's Republic of ChinaKey Laboratory of Superlight Materials and Surface Technology,Ministry of Education,College of Materials Science and Chemical Engineering,Harbin Engineering University,Harbin 150001,People's Republic of China||Yantai Research Institute,Harbin Engineering University,Yantai 264000,People's Republic of ChinaKey Laboratory of Green Chemical Engineering and Technology of Heilongjiang Province,College of Material Science and Chemical Engineering,Harbin University of Science and Technology,Harbin 150040,People's Republic of ChinaDepartment of Chemistry,Quaid-i-Azam University,Islamabad 45320,Pakistan
NanozymesClassificationPrediction and designCatalytic mechanismTumor theranostics
《纳微快报（英文）》 2024 (002)
165-217 / 53
S.G.acknowledges the financial support from the National Natural Science Foundation of China(NSFC 52272144,51972076),the Heilongjiang Provincial Natural Science Foundation of China(JQ2022E001),the Natural Science Founda-tion of Shandong Province(ZR2020ZD42),and the Fundamental Research Funds for the Central Universities.H.D.acknowledges the financial support from the National Natural Science Foundation of China(NSFC22205048),China Postdoctoral Science Founda-tion(2022M710931 and 2023T160154),Heilongjiang Postdoctoral Science Foundation(LBH-Z22010).G.Y.acknowledges the finan-cial support from the National Science Foundation of Heilongjiang Education Department(324022075).Open access funding provided by Shanghai Jiao Tong University.
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