Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue MonitoringOACSTPCD
Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring
Implantable hydro-gel-based bioelectronics(IHB)can precisely monitor human health and diagnose diseases.However,achieving biodegradability,bio-compatibility,and high conformal-ity with soft tissues poses signifi-cant challenges for IHB.Gelatin is the most suitable candidate for IHB since it is a collagen hydro-lysate and a substantial part of the extracellular matrix found natu-rally in most tissues.This study used 3D printing ultrafine fiber net-works with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical programmability.The regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson's ratio from-0.25 to 0.52.The negative Poisson's ratio promotes conformality with soft tissues to improve the efficiency of biological interfaces.The GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high conformability.Notably,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue restoration.The GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.
Yuewei Chen;Qing Gao;Zhijian Xie;Jiachun Li;Yong He;Yanyan Zhou;Zihe Hu;Weiying Lu;Zhuang Li;Ning Gao;Nian Liu;Yuanrong Li;Jing He
State Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,People's Republic of China||School of Mechanical Engineering,Guizhou University,Guiyang 550025,People's Republic of ChinaState Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,People's Republic of ChinaStomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Clinical Research Center for Oral Diseases of Zhejiang Province,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Hangzhou 310006,People's Republic of ChinaSchool of Mechanical Engineering,Guizhou University,Guiyang 550025,People's Republic of China
Implantable hydrogel-based bioelectronicsConformality3D printingMetamaterial design
《纳微快报（英文）》 2024 (002)
347-364 / 18
This work was sponsored by the National Natural Science Foundation of China(No.52235007,52325504)and the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004).Open access funding provided by Shanghai Jiao Tong University.
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