现代妇产科进展2023，Vol.32Issue(12)：885-889,893,6.DOI:10.13283/j.cnki.xdfckjz.2023.12.002
卵巢低级别浆液性癌患者的临床特点分析
Clinical features of low-grade serous ovarian cancer
摘要
Abstract
Objective:To explore the clinical features and treatment strategy of patients with low-grade serous ovarian cancer.Methods:Medical records of 44 patients with low-grade serous ovarian cancer who underwent treatment at Peking University People's Hospital from Jan-uary 2010 to June 2020 were analyzed,including the age at diagnosis,FIGO stage,primary sur-gery,first-line chemotherapy,endocrine therapy,recurrence treatment and other data.Kaplan-Meier survival curves were used to analyze the progression-free survival and overall survival of the patients.Results:The median age at diagnosis was 38 years old,and FIGOⅢwas the most common at diagnosis(52.3%).The main initial treatment was primary surgery followed by platinum-based adjuvant chemotherapy,and the rate of complete gross resection and optimal cy-toreduction at primary cytoreductive surgery were 63.2%and 79.0%respectively.6 patients underwent neoadjuvant chemotherapy,and the objective response rate was 83.3%(5/6).5 pa-tients underwent interval cytoreductive surgery and all of them had no residual tumor.42 pa-tients had complete or partial response after initial treatment.14 patients(33.3%)experienced at least one recurrence.At first recurrence,the main treatment was surgery,at the same time,platinum-based chemotherapy and endocrine therapy were also important.The median follow-up time was 73.0 months.The median progression-free survival after initial treatment was 83.0 months.5-year survival rate was 85.2%,and the median overall survival was not reached.Con-clusion:Most patients with low-grade serous ovarian cancer were diagnosed at young age.StageⅢ was the most common disease.Regardless of first diagnosis and recurrence,surgery was the most important treatment,and should be aimed at no residual tumor.The first-line chemotherapy was platinum-based combination regimen.Although low-grade serous ovarian cancer was rela-tively chemoresistant,patients with advanced disease could also be considered to receive neoad-juvant chemotherapy.Endocrine therapy also played an important role in the treatment of low-grade serous ovarian cancer.The prognosis was better than that of high-grade serous ovarian cancer.关键词
卵巢癌/低级别浆液性癌/临床特点/治疗策略Key words
Ovarian carcinoma/Low-grade serous carcinoma/Clinical features/Treat-ment strategy分类
医药卫生引用本文复制引用
窦莎,王元芬,李艺..卵巢低级别浆液性癌患者的临床特点分析[J].现代妇产科进展,2023,32(12):885-889,893,6.基金项目
国家重点研发计划(No:2022YFC2704204) （No:2022YFC2704204）
