现代妇产科进展2023，Vol.32Issue(12)：904-907,913,5.DOI:10.13283/j.cnki.xdfckjz.2023.12.005
宫腔灌注自体外周血单个核细胞改善反复种植失败患者的妊娠结局
Intrauterine infusion of autologous peripheral blood mononuclear cells improves preg-nancy outcomes in patients with repeated implantation failure
摘要
Abstract
Objective:To observe the clinical effect of intrauterine infusion of autolo-gous peripheral blood mononuclear cells(PBMCs)at different times before embryo transfer in patients with repeated implantation failure(RIF).Methods:From January 2021 to October 2022,195 patients who failed to undergo freezing embryo transplantation in the reproductive center of our hospital were collected.Patients with autologous peripheral blood mononuclear cells intrauterine perfusion as the observation group(105 cases),divided into 3 subgroups,72 hours before embryo transfer intrauterine perfusion PBMCs group I(35 cases),48 hours before embryo transfer intrauterine perfusion PBMCs group Ⅱ(37 cases).Intrauterine perfusion of PBMCs 24 hours before embryo transfer was performed in Group Ⅲ(33 cases).Patients with repeated implantation failure without intrauterine perfusion before embryo transfer were the con-trol group(90 cases).The general situation,embryo transfer situation,embryo implantation rate,clinical pregnancy rate,early abortion rate,ectopic pregnancy rate and live birth rate were compared between the observation group and the control group and among the subgroups of the observation group.Results:There was no statistical significance in the general situation and em-bryo transfer between the observation group and the control group(all P＞0.05).The clinical pregnancy rate(28.9%),embryo implantation rate(21.1%)and live birth rate(23.3%)in observation group were higher than those in control group(44.8%,31.9%,38.1%),the differences were statistically significant(all P＜0.05).There was no significant difference in the early abortion rate(15.4%vs 10.6%)between the two groups(P＞0.05).There was no significant difference in the general situation and embryo transfer among the subgroups in the observation group(all P＞0.05),The clinical pregnancy rate(42.9%,48.6%,42.4%),em-bryo implantation rate(28.6%,38.1%,28.6%),live birth rate(34.3%,43.2%,36.4%)and early abortion rate(13.3%,5.6%,14.3%)among groups I,II and III were observed were not statistically significant(all P＞0.05).Conclusion:Intrauterine perfusion of autologous peripheral blood mononuclear cells can improve the pregnancy outcome of patients with repeated implantation failure,and there is no difference in clinical outcome of intrauterine perfusion 24-72 hours before embryo transfer.关键词
外周血单个核细胞(PBMC)/宫腔灌注/子宫内膜容受性/胚胎移植/反复种植失败Key words
Peripheral blood mononuclear cells(PBMC)/Uterine perfusion/Endome-trial receptivity/Embryo transfer/Repeated implantation failure分类
医药卫生引用本文复制引用
刘珊,贾君,高艳霞,吴园园,刘荣娜,程立立,吴小华..宫腔灌注自体外周血单个核细胞改善反复种植失败患者的妊娠结局[J].现代妇产科进展,2023,32(12):904-907,913,5.基金项目
河北省卫建委科研计划项目(No:20220254) （No:20220254）
