摘要
Abstract
Objective:To explore the risk factors associated with ovarian involvement in endometrial cancer(EC)and the value of mismatch repair protein expression in predicting ovar-ian involvement in EC,and to provide a reference for clinical ovarian preservation in young women.Methods:782 EC patients who accepted surgical intervention at Qilu Hospital of Shan-dong University from January 2019 to January 2022 were analyzed.Clinicopathologic character-istics were collected from all patients and MMR status was determined using immunohistochem-istry.Results:Univariate analysis revealed that non-endometrioid type,high-grade,tumor diame-ter＞4cm,uterine horn/fallopian tube or lower uterine segment/cervix involvement,deeper myo-metrial invasion,lymph node metastasis,lymph-vascular space invasion were associated with o-varian involvement in EC patients.Multivariate analysis revealed that only tumor size and tumor location were independent risk factors.Among 97 young EC patients(aged≤45 years),9 had coexisting ovarian tumors.All cases were endometrioid histology and 8 had suspicious ovarian masses on preoperative imaging.Patients with MMR-deficient tumours were older and had more lymph-vascular space invasion(LVSI)than patients with MMR-proficient tumours.However,no significant difference was found in the rate of ovarian involvement between the two groups.Con-clusion:In young EC patients,to further evaluate the safety of ovarian preservation,preoperative imaging and hysteroscopy can be used to assessment tumor size,tumor location and adnexa.The risk of ovarian involvement in EC is not associated with MMR status,indicating that MMR status may not need to be considered when making decisions about ovarian preservation.关键词
子宫内膜癌/卵巢受累/卵巢转移/同步性子宫内膜卵巢癌/错配修复蛋白Key words
Endometrial cancer/Ovarian involvement/Ovarian metastasis/Synchro-nous endometrial and ovarian cancer/Mismatch repair分类
医药卫生
