畜牧兽医学报2023，Vol.54Issue(12)：4898-4909,12.DOI:10.11843/j.issn.0366-6964.2023.12.002
动物早期胚胎发育中表观重编程的机制
Mechanism of Epigenetic Reprogramming of Early Animal Embryos
摘要
Abstract
During mammalian early embryonic development,the fertilized egg undergoes a series of epigenetic reprogramming events,erasing the epigenetic memory of the parental nuclei and establishing the embryonic totipotency.However,the exact regulation of these reprogramming events by species-specific mechanisms calls for more research into the subject.Significant success has been made in understanding the regulatory network of epigenetic reprogramming during early mammalian embryonic development thanks to the ongoing development of molecular biology techniques,particularly the innovations in low-input whole-genome chromatin analysis.The goal of this paper is to outline recent developments in the mechanisms of epigenetic reprogramming in model animals and different livestock,including work on DNA methylation,histone modifica-tions,chromatin accessibility,and chromatin 3D structure.关键词
早期胚胎发育/表观遗传重编程/DNA甲基化/组蛋白修饰/染色质结构Key words
early embryonic development/epigenetic reprogramming/DNA methylation/histone modification/chromatin structure分类
农业科技引用本文复制引用
张宸艺博,余彤,任斌斌,郑睿智,朱文治,苏建民..动物早期胚胎发育中表观重编程的机制[J].畜牧兽医学报,2023,54(12):4898-4909,12.基金项目
国家自然科学基金(32172812) （32172812）
青海省重点研发与转化计划(2023-NK-131) （2023-NK-131）
