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PREX1基因与肿瘤发病机制关系的研究进展

陈婷周宇

新医学2023，Vol.54Issue(12)：845-848,4.

新医学2023，Vol.54Issue(12)：845-848,4.DOI:10.3969/j.issn.0253-9802.2023.12.001

PREX1基因与肿瘤发病机制关系的研究进展

Research progress in the relationship between PREX1 gene and tumor pathogenesis

陈婷 ¹周宇¹

作者信息

1. 524000 湛江,广东医科大学附属医院消化内科
折叠

摘要

Abstract

Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1(PREX1)is a coding gene that is abnormally expressed in a variety of tumors.As a guanine nucleotide exchange factor(RacGEF)of small GTP binding protein Rac1,PREX1 gene-encoded protein can form PREX1/Rac pathway through activating Rac1,crosstalk with a variety of classical signaling pathways,participate in the regulation of various receptor reactions in the tumor process,affect the epithelial-mesenchymal transformation process of the tumor microenvironment and play a role in tumor proliferation,metastasis and prognosis.

关键词

磷脂酰肌醇-3,4,5-三磷酸依赖性Rac交换因子1基因/信号通路/上皮-间充质转化/肿瘤/发病机制

Key words

Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 gene/Signaling pathway/Epithelial-mesenchymal transformation/Tumor/Pathogenesis

引用本文复制引用

陈婷,周宇..PREX1基因与肿瘤发病机制关系的研究进展[J].新医学,2023,54(12):845-848,4.

新医学

OACSTPCD

ISSN：0253-9802

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