新医学2023，Vol.54Issue(12)：884-888,5.DOI:10.3969/j.issn.0253-9802.2023.12.008
Egr3、IL-6、TNF-α与冠心病严重程度的相关性分析
Correlation analysis of Egr3,IL-6,TNF-α and the severity of coronary heart disease
摘要
Abstract
Objective To investigate the correlation between early growth response factor 3(Egr3),pro-inflammatory cytokines IL-6 and TNF-α and coronary atherosclerotic heart disease(CHD).Methods A total of 138 patients with confirmed CHD were collected,all of whom underwent coronary angiography and were divided into 2 groups based on the results of coronary angiography and Gensini score,including 66 patients in the mild stenosis group and 72 patients in the severe stenosis group,and 47 subjects with normal coronary angiography results were selected as the control group.Serum levels of Egr3,IL-6 and TNF-α were detected by ELISA.The general clinical data of the subjects were collected,and the differences of Egr3,IL-6 and TNF-α levels among all groups were compared to explore the relationship between the levels of EGR3 and Gensini scores.Results The serum levels of Egr3 and IL-6 in severe stenosis group were higher than those in control group and mild stenosis group,and the level of TNF-α in severe stenosis group was higher than that in control group,with statistical significance(all P<0.05).The subject operation characteristic(ROC)curve showed that the area under the curve(AUC)of Egr3,IL-6 and TNF-α were 0.769,0.784 and 0.565,respectively,and Egr3 had a good predictive value for CHD.Conclusion Egr3,IL-6 and TNF-α are highly expressed in CHD patients,and Egr3 can be used as an indicator to judge the severity of CHD patients.关键词
早期生长反应因子3/冠状动脉粥样硬化性心脏病/白介素-6/肿瘤坏死因子-α/炎症Key words
Early growth factor 3/Coronary heart disease/Interleukin-6/Tumor necrosis factor-α/Inflammation引用本文复制引用
王思晴,祖姆热提·阿布都克依木,李霞..Egr3、IL-6、TNF-α与冠心病严重程度的相关性分析[J].新医学,2023,54(12):884-888,5.基金项目
国家自然科学基金(81960073) （81960073）
